Effects of resveratrol on mast cell degranulation and tyrosine phosphorylation of the signaling components of the IgE receptor

Planta medica
NaYeon KooKyeong-Man Kim

Abstract

The molecular mechanism of how resveratrol inhibits mast cell degranulation was studied by examining its effects on the signaling components of the high affinity IgE receptor (FcepsilonRI) pathway. Resveratrol inhibited mast cell degranulation in a dose-dependent manner and reduced the FcepsilonRI-mediated tyrosine phosphorylation of ERK and PLCgamma1 but not of Syk and PLCgamma2. U-73 122 and PD98059, which are PLC and MEK inhibitors, also had inhibitory effects on mast cell degranulation. These results suggest that FcepsilonRI-mediated tyrosine phosphorylation of PLCgamma1 and ERK could be potential cellular targets of resveratrol for the inhibition of mast cell degranulation.

Citations

Mar 25, 2011·Critical Reviews in Food Science and Nutrition·R GonzálezF Sánchez de Medina
Nov 24, 2007·Journal of Food Science·Sun Phil ChoiMendel Friedman
May 15, 2019·Cells·Edoardo ParrellaMarina Pizzi
Sep 26, 2020·Frontiers in Pharmacology·Astrid HogenkampLinette E M Willemsen

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