Effects of resveratrol supplementation on liver fat content in overweight and insulin-resistant subjects: A randomized, double-blind, placebo-controlled clinical trial

Diabetes, Obesity & Metabolism
Konstantinos KantartzisNorbert Stefan

Abstract

We performed the largest randomized, placebo-controlled clinical trial to date (N = 112, 12-week intervention) to investigate the effects and safety of resveratrol supplementation on liver fat content and cardiometabolic risk parameters in overweight and obese and insulin-resistant subjects. At baseline the variability in liver fat content was very large, ranging from 0.09% to 37.55% (median, 7.12%; interquartile range, 3.85%-12.94%). Mean (SD) liver fat content was 9.22 (6.85) % in the placebo group and 9.91 (7.76) % in the resveratrol group. During the study liver fat content decreased in the placebo group (-0.7%) but not in the resveratrol group (-0.03%) (differences between groups: P = .018 for the intention-to-treat [ITT] population; N = 54, resveratrol, N = 54, placebo and P = .0077 for the per protocol [PP] population). No effects of resveratrol supplementation on cardiometabolic risk parameters were observed. Resveratrol supplementation was well tolerated and safe. In conclusion, these data suggest that resveratrol supplementation is safe and that it does not considerably impact liver fat content or cardiometabolic risk parameters in humans.

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Citations

Apr 16, 2018·Diabetes, Obesity & Metabolism·Federica FogacciArrigo Francesco Giuseppe Cicero
Nov 14, 2018·Critical Reviews in Food Science and Nutrition·Reza TabriziZatollah Asemi
Jul 3, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Maryam AkbariZatollah Asemi
Jun 4, 2020·The American Journal of Clinical Nutrition·Marlies de LigtPatrick Schrauwen
Sep 2, 2020·International Journal of Clinical Practice·Mina DarandGholamreza Askari
Oct 4, 2020·Pharmaceuticals·Jenifer TrepianaMaría Puy Portillo
Mar 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika JarosovaJaroslav Havlik
Jan 4, 2019·European Journal of Nutrition·Pedro L ValenzuelaAlejandro Lucia
Aug 6, 2020·Nutrients·Brittanie KilchoerLia Bally
Oct 5, 2018·Digestive Diseases and Sciences·Xiaoling JinLeonidas G Koniaris
Jan 3, 2020·European Journal of Gastroenterology & Hepatology·Eduardo E Vargas-Pozada, Pablo Muriel
Nov 5, 2020·Food & Function·I Milton-LaskibarM P Portillo
Jan 13, 2021·Antioxidants·Beatriz Isabel García-MartínezVíctor Manuel Mendoza-Núñez
Jan 23, 2021·Critical Reviews in Food Science and Nutrition·Felipe Mendes Delpino, Lílian Munhoz Figueiredo
Dec 18, 2020·International Journal of Molecular Sciences·David E Stec, Terry D Hinds
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Jul 26, 2021·European Journal of Pharmacology·Melodi OmraninavaAmirhossein Sahebkar
Sep 3, 2021·Phytotherapy Research : PTR·Armita Mahdavi GorabiAmirhossein Sahebkar
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Jul 6, 2021·Phytotherapy Research : PTR·Dharmani Devi MuruganPooi-Fong Wong

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