Effects of resveratrol treatment on bone and cartilage in obese diabetic mice

Journal of Diabetes and Metabolic Disorders
Joseph CooleyJeffrey H Plochocki

Abstract

Resveratrol is a polyphenolic phytoalexin that has been shown to exhibit osteoprotective and chondroprotective properties. We examine the effects of resveratrol treatment on bone and cartilage tissue of obese, diabetic ob/ob mice. Eight-week-old ob/ob and lean control mice were given trans-resveratrol at an oral dose of 25 mg/kg for 3 weeks. Histomorphometric and cross-sectional-geometric variables were analyzed. Ob/ob mice in our study exhibit significantly reduced femoral length, resistance to loading, and tibial growth plate total area and calcified area than lean controls (P < 0.05). Resveratrol treatment significantly increased cortical area in both ob/ob and control mice, but did not improve cross-sectional indicators of resistance to bending. Resveratrol treatment also reduced tibial length and calcified growth plate cartilage area in comparison to untreated mice (P < 0.05). Resveratrol treatment of ob/ob mice had mixed effects on bone histomorphometry at the femoral midshaft. Treatment increased cortical area but decreased bone length.

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Citations

Jun 26, 2017·Biochemical and Biophysical Research Communications·Xia KangKen Chen
Feb 12, 2017·BMC Endocrine Disorders·Britton OdleJeffrey H Plochocki
Feb 6, 2019·BMC Complementary and Alternative Medicine·Mustafa F AlkhouliJeffrey H Plochocki
Mar 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Da JingZhuojing Luo
Jan 31, 2019·Diabetology & Metabolic Syndrome·Jun HungJeffrey H Plochocki

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