Effects of retigabine on rhythmic synchronous activity of human neocortical slices

Epilepsy Research
H StraubE Speckmann

Abstract

The antiepileptic effects of the novel antiepileptic drug retigabine (D-23129) [N-(2-amino-4-(4-flurobenzylamino)phenyl) carbamid acid ethyl ester] were tested in neocortical slice preparations (n=23) from 17 patients (age, 3-42 years) who underwent surgery for the treatment of intractable epilepsy. Epileptiform events consisted of spontaneously occurring rhythmic sharp waves, as well as of epileptiform field potentials (EFP) elicited by superfusion with Mg(2+)-free solution without or with addition of 10 micromol/l bicuculline. (1) Spontaneous rhythmic sharp waves (n=6), with retigabine application, the repetition rate was decreased down to 12-47% of initial value (10 micromol/l, n=3) after 180 min or suppressed completely within 12 min (50 micromol/l, n=3). (2) Low Mg(2+) EFP (n=9), with retigabine application, the repetition rate was decreased down to 50 and 65% of initial value (10 micromol/l; n=2) after 180 min or suppressed completely after 9-55 min (10, 50 and 100 micromol/l; n=2 in each case). In one slice only a transient reduction of the repetition rate was seen with 10 micromol/l retigabine. (3) Low Mg(2+) EFP with addition of bicuculline (n=8), with retigabine application, the repetition rate was decreased down to 1...Continue Reading

References

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Citations

Sep 24, 2005·Anatomy and Embryology·A GorjiE-J Speckmann
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Roger J PorterChris Rundfeldt
Dec 4, 2002·Epilepsia·Ali GorjiErwin-Joseph Speckmann
Nov 1, 2011·Drugs·Cinzia Fattore, Emilio Perucca
May 4, 2005·CNS Drug Reviews·G Blackburn-MunroR E Blackburn-Munro
Jul 10, 2003·British Journal of Clinical Pharmacology·Geraldine M FerronSteven M Troy
Jul 13, 2012·Expert Opinion on Pharmacotherapy·Gökce OrhanHolger Lerche
Sep 24, 2013·Expert Opinion on Drug Discovery·Slobodan Jankovic, Ivana Ilickovic
Sep 23, 2006·Expert Opinion on Investigational Drugs·Thomas V Wuttke, Holger Lerche
Jan 26, 2021·Epilepsia·Marco de CurtisLaura Uva
Mar 24, 2021·Expert Opinion on Therapeutic Targets·E S Nikitin, L V Vinogradova

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