Effects of retinoic acid combined with irradiation on the expression of major histocompatibility complex molecules and adhesion/costimulation molecules ICAM-1 in human cervical cancer

Gynecologic Oncology
A D SantinG P Parham

Abstract

Radiation treatment is one of the most standardized and effective modalities for contemporary cervical cancer therapy. In addition, the radiation-potentiating effects of retinoic acid have been recently described. In order to investigate whether enhanced immunogenicity might be responsible for such potentiation, we have evaluated the effects of retinoic acid combined with high doses of gamma-irradiation on the expression of major histocompatibility complex (MHC) Class I and II and intercellular adhesion molecule-1 (ICAM-1) in human cervical carcinoma cell lines. The expression of surface antigens (MHC Class I and II and ICAM-1) was evaluated by FACS analysis in untreated control cells and in cells following their exposure to retinoic acid, high doses of gamma-irradiation (i.e., 5000 and 10,000 cGy), or the combination of the two procedures. HT-3 and SiHa cervical cancer cells expressed variable levels of MHC Class I and ICAM-1 antigens while Class II surface antigens were not detectable. Exposure to either 5000 or 10,000 cGy completely inhibited cell replication in both cell lines and significantly and consistently increased the expression of all surface antigens present on the cells prior to irradiation. Irradiation was unable...Continue Reading

References

Feb 1, 1992·International Journal of Immunopharmacology·X L JiangE W Lamon
Dec 15, 1990·International Journal of Cancer. Journal International Du Cancer·M E Connor, P L Stern
Oct 15, 1986·International Journal of Cancer. Journal International Du Cancer·J E de VriesC G Figdor
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·H P Rutz, J B Little
Apr 15, 1987·International Journal of Cancer. Journal International Du Cancer·N GrossS Carrel
Jun 1, 1994·International Journal of Cancer. Journal International Du Cancer·S HonmaK Tanaka
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·N Coleman, M A Stanley

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Citations

Jun 16, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Kenneth W HanceJohn W Greiner
Dec 1, 2006·Veterinary and Comparative Oncology·D H Thamm
Feb 18, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·P HatfieldA Melcher
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·Eiichi IshikawaTadao Ohno

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