Effects of retinoic acid on the growth of cultured rabbit articular chondrocytes: Relation with alkaline phosphatase activity and beta receptor.

Cytotechnology
N DronneM Adolphe

Abstract

The effects of retinoic acid (RA) on rabbit articular cartilage cells were studied for concentrations ranging from 5.10(-5) M to 10(-7) M; the treatment with RA over three days resulted in dose dependent inhibition of chondrocyte proliferation between 5.10(-5) and 10(-5) M with persistence of the inhibitory effect until 10(-6) M. RA until 10(-7) M induced a slight, but significant, enhancement of cell proliferation. This growth stimulating effect seems to be related to the Beta receptor system because Beta blockers, such as sotalol and DL propranolol, were able to suppress the stimulating action of agonist type isoprenaline. The activity of alkaline phosphatase (AP) was also determined. The highest dose of RA (5.10(-5) M) induced an increase (x 3) of AP activity, and 10(-7) M RA decreased it (x 0.4).

References

Mar 1, 1971·Clinical Orthopaedics and Related Research·W T Green
Oct 1, 1983·Mechanisms of Ageing and Development·M AdolpheP Lechat
Oct 1, 1980·Experimental Cell Research·M PacificiF Tato

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Citations

Oct 22, 2005·Journal of Internal Medicine·J R E Fraser, P R Gibson
Sep 1, 1996·Acta Neurologica Scandinavica·U B LaurentK Lilja

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