PMID: 9443367Jan 1, 1997Paper

Effects of reversible inactivation of the supplementary motor area (SMA) on unimanual grasp and bimanual pull and grasp performance in monkeys

Somatosensory & Motor Research
I KermadiE M Rouiller

Abstract

The supplementary motor area (SMA) was reversibly inactivated by muscimol microinfusion in two monkeys while they were performing two motor tasks: (1) a delayed conditional bimanual drawer pulling and grasping sequence which was initiated on a self-paced basis; (2) a unimanual reach and grasp task (modified Kluver board task). Unilateral or bilateral inactivation of the SMA induced a prominent deficit in trial initiation of bimanual sequential movements, affecting the hand contralateral to the inactivated side or both hands, respectively. The deficit was a long lasting (10-15 min or more) inability of the monkey to place its hand (s) in the ready position on start touch-sensitive pads, a condition required to initiate the drawer task. However, if after such a deficit period, the experimenter put his hand on the start touch-sensitive pad to initiate the trial, then the monkey executed the drawer task without obvious motor deficit. SMA inactivation did not affect unimanual reaching and grasping movements in the board task. In contrast to the SMA, inactivation of other motor areas (primary, premotor dorsal, anterior intraparietal area) did not affect the initiation of movement sequences in the drawer task. These data thus indicate...Continue Reading

Citations

Jun 10, 2010·Experimental Brain Research·Scott T Grafton
May 4, 2002·Nature Reviews. Neuroscience·Stephan P Swinnen
Nov 23, 2011·Journal of Visualized Experiments : JoVE·Eric SchmidlinEric M Rouiller
Nov 2, 2002·The Journal of Comparative Neurology·Judith Tanné-GariépyEric M Rouiller
Jun 28, 2011·Experimental Neurology·Warren G DarlingRobert J Morecraft
Aug 15, 2009·Experimental Neurology·Warren G DarlingRobert J Morecraft
Jun 17, 2015·NeuroImage·Andrea CavalloLuciano Fadiga
Jul 24, 2008·Human Brain Mapping·Tao WuPiu Chan
Jul 1, 2001·Proceedings of the IEEE·Tzyy-Ping JungTerrence J Sejnowski
Jun 29, 2004·NeuroImage·Susan KoenekeLutz Jäncke
Apr 20, 2006·Parkinsonism & Related Disorders·Mirthe M PonsenHenk W Berendse
Aug 23, 2008·NeuroImage·R R WalshA Solodkin
Mar 26, 2014·PloS One·Murielle Ursulla FerrayeIvan Toni
Dec 5, 2003·Progress in Brain Research·Mario Wiesendanger, Deborah J Serrien
Aug 14, 2012·Journal of the International Neuropsychological Society : JINS·Adam D FalchookKenneth M Heilman
Jun 8, 2007·Journal of Neurophysiology·Marc A PizzimentiRobert J Morecraft
Aug 25, 2019·Scientific Reports·A A Nogueira-CamposT Pozzo
May 1, 2004·Motor Control·Sukhvinder S Obhi
Aug 20, 2003·The European Journal of Neuroscience·B MarconiR Caminiti
Apr 19, 2011·Experimental Brain Research·Deirdre BirtlesOliver Braddick
Apr 30, 2021·Frontiers in Psychology·Annabel Wing-Yan FanJonathan S Cant

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