Effects of rhG-CSF on infection complications and impaired function of neutrophils secondary to chemotherapy for non-Hodgkin's lymphoma. Hokkaido Study Group of Malignant Lymphoma, and rhG-CSF, Japan

Leukemia & Lymphoma
Y Kuni-EdaN Fujimoto

Abstract

It has been previously demonstrated that the administration of recombinant human granulocyte-colony stimulating factor (rhG-CSF) ameliorates the decrease of the polymorphonuclear neutrophils (PMNs) count after the cytotoxic chemotherapies, thereby reducing the infection complications associated with neutropenia. In this multi-center study, we studied the prophylaxtic effect of rhG-CSF administration on infection complications in patients with non-Hodgkin malignant lymphoma, who received cytotoxic chemotherapies (CHOP or ProMACE/CytaBOM). rhG-CSF administration reduced the frequency of infection complications, and there was no obvious difference in it's frequency between the CHOP-treated and the ProMACE/CytaBOM-treated groups when administered with rhG-CSF, thereby indicating that third generation therapy for NHL may be safely completed in Japanese in combination with rhG-CSF administration. Furthermore, we investigated both the in vitro and the in vivo effects of rhG-CSF on the function of PMNs in patients with NHL and healthy donors, and revealed that the administration of rhG-CSF for NHL patients receiving cytotoxic chemotherapy brought on an improvement of the production of active oxygen but did not affect serum levels of IF...Continue Reading

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Citations

Sep 29, 1999·Genes, Chromosomes & Cancer·E Callet-BauchuP Felman
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I RasulE J Heathcote
Apr 26, 2003·Mechanisms of Ageing and Development·Anja Kristina Schröder, Lothar Rink
Jul 28, 2006·The American Journal of Dermatopathology·Arnaud de la FouchardiereFrançoise Berger
Jan 22, 2013·Veterinary and Comparative Oncology·A K LeblancS A Kania
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed L SalemDavid J Cole

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