Effects of rhynchophylline on the hippocampal miRNA expression profile in ketamine-addicted rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
Chan LiZhi-Xian Mo

Abstract

In the past few years, ketamine, a noncompetitive NMDA antagonist, has been widely abused worldwide as a new type of synthetic drug, severely affecting the physical and mental health of ketamine abusers. Previous studies have suggested that rhynchophylline can alleviate drug abuse and reverse the conditioned place preference caused by the abuse. MicroRNAs (miRNAs) are important factors regulating gene expression and are involved in the drug addiction process. The hippocampus is a critical area in the brain involved in causing drug addiction. However, the hippocampal miRNA expression profile and the effects of rhynchophylline on miRNA expression during ketamine abuse have not been reported. Thus, this study analyzed the hippocampal miRNA expression profile during ketamine-dependence formation and the effects of rhynchophylline on the differential expression of miRNAs induced by ketamine. The results of microarray analysis suggested that the expression levels of miR-331-5p were significantly different among three groups (the control, ketamine, and ketamine + rhynchophylline groups). miR-331-5p levels were significantly decreased in the ketamine model group and were upregulated in the ketamine + rhynchophylline group. Bioinformati...Continue Reading

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Citations

Sep 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinying OuZhixian Mo
Jul 3, 2021·Clocks & Sleep·Maria Neus Ballester RoigValérie Mongrain
Aug 25, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mehdi ZobeiriMohammad Abdollahi

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