PMID: 11310635Apr 20, 2001Paper

Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis

Annals of Neurology
K StefanJ Classen

Abstract

Using transcranial magnetic stimulation, the effect of riluzole (RLZ) on cortical excitability was studied in patients with amyotrophic lateral sclerosis (ALS). Paired-pulse inhibition (PPI) and paired-pulse facilitation (PPF) were reduced. RLZ partially restored deficient PPI in the first of 4 consecutive 3-month periods of testing, but left PPF unchanged. These findings substantiate the view that attenuation of glutamate-related excitotoxicity is an important factor contributing to the beneficial effect of RLZ in ALS.

Citations

Dec 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A Eisen, M Swash
Nov 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giampietro ZanetteNicola Rizzuto
Nov 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Babak Boroojerdi
Aug 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·M R TurnerK R Mills
Sep 1, 2009·Experimental Neurology·Steve VucicMatthew C Kiernan
Dec 25, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Steve VucicMatthew C Kiernan
Jun 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·William HuynhMatthew C Kiernan
Jul 17, 2010·Brain Stimulation·Vincenzo Di LazzaroPietro A Tonali

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