Effects of rimonabant, as monotherapy and in combination with fenofibrate or ezetimibe, on plasma adipokine levels: a pilot study

Angiology
M FlorentinA D Tselepis

Abstract

Weight loss and hypolipidemic drugs can improve lipid and adipokine levels. We assessed the effects of rimonabant, alone and in combination with fenofibrate or ezetimibe, on adipokine levels in obese/overweight patients with dyslipidemia. Overweight/obese patients (n = 60, body mass index = 27-40 kg/m(2)) with mixed dyslipidemia were recruited. Patients received a hypocaloric diet and were randomized to rimonabant 20 mg/d (group R, n = 20), rimonabant 20 mg/d plus fenofibrate 200 mg/d (group RF, n = 20), or rimonabant 20 mg/d plus ezetimibe 10 mg/d (group RE, n = 20). After 3 months, leptin concentration was significantly reduced in all groups (-38%, P < .005; -40%, P < .005; and -44%, P < .001 in the R, RF, and RE groups, respectively). Total adiponectin remained unaltered. Visfatin concentration decreased significantly only in the RE and RF groups (-18% and -38%, respectively; P < .047). Treatment with rimonabant may improve adipokine levels in overweight/obese patients with dyslipidemia. The addition of fenofibrate or ezetimibe may reinforce this effect.

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Apr 15, 2000·Nature·M W SchwartzD G Baskin
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Oct 19, 2002·Circulation Research·Hideo Kusuoka, Julien I E Hoffman
Jan 14, 2005·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Jonas AxelssonPeter Stenvinkel
Apr 28, 2005·Nature Neuroscience·Heike Münzberg, Martin G Myers
Jul 12, 2005·Trends in Molecular Medicine·Jaswinder K Sethi, Antonio Vidal-Puig
Nov 18, 2005·The New England Journal of Medicine·Jean-Pierre DesprésUNKNOWN Rimonabant in Obesity-Lipids Study Group
Nov 25, 2005·Endocrine Reviews·Uberto PagottoRenato Pasquali
Dec 30, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Aki HiugeTohru Funahashi
Mar 30, 2007·Journal of Clinical Pharmacology·Anna I KakafikaVasilios G Athyros
May 24, 2007·Current Medical Research and Opinion·Mihalis KalogirouMoses Elisaf
Oct 3, 2007·The Journal of Clinical Investigation·Kevin D Niswender, Mark A Magnuson
Oct 13, 2007·European Journal of Pharmacology·Michael S KostapanosMoses S Elisaf
Jan 5, 2008·European Journal of Clinical Investigation·T D FilippatosM S Elisaf
Dec 30, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésUNKNOWN ADAGIO-Lipids Investigators
May 12, 2009·Journal of Cardiovascular Medicine·Ayman El-MenyarJassim Al Suwaidi
Jun 3, 2009·Current Vascular Pharmacology·Theodosios D FilippatosDimitri P Mikhailidis
Jul 9, 2009·JAMA : the Journal of the American Medical Association·Shanshan LiRob M van Dam
Sep 3, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·Matilda FlorentinEvangelos N Liberopoulos

❮ Previous
Next ❯

Citations

Nov 12, 2013·Metabolic Syndrome and Related Disorders·Ali A RizviNicola Abate
Jan 26, 2011·Expert Opinion on Therapeutic Targets·Niki KatsikiDimitrios Karamitsos
Feb 7, 2017·British Journal of Clinical Pharmacology·Eva DolezelovaAmirhossein Sahebkar
Jan 25, 2013·The Open Cardiovascular Medicine Journal·Ioanna PaspalaAnna Tsiligiroglou-Fachantidou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.