PMID: 43475Nov 1, 1979

Effects of ring substitution on the pre- and postjunctional alpha-adrenergic activity of aryliminoimidazolidines

Naunyn-Schmiedeberg's Archives of Pharmacology
J P Hieble, R G Pendleton

Abstract

The pre- and postjunctional alpha-adrenergic agonist potency of a series of aryliminoimidazolidines was determined in the isolated rabbit ear artery. This series included clonidine, an antihypertensive agent thought to act by stimulating brainstem alpha-receptors and known to be a preferentially prejunctional alpha-adrenergic agonist. Although all of the compounds acted preferentially on the prejunctional alpha-adrenoceptor, ring substitution had a dramatic effect on both potency and the degree of selectivity. 2-(3,4-Dihydroxyphenylimino) imidazolidine was both the most potent and most selective prejunctional alpha-agonist in this series.

References

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Nov 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·J P Hieble, D F Woodward
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Citations

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
Nov 1, 1975·The Journal of Pharmacy and Pharmacology·H Struyker BoudierJ van Rossum
Aug 1, 1976·Journal of Medicinal Chemistry·B RouotC G Wermuth
Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
May 1, 1977·British Journal of Pharmacology·J C DoxeyJ M Walker
Sep 1, 1977·Life Sciences·S Berthelsen, W A Pettinger
Jan 15, 1978·European Journal of Pharmacology·A Walland
Jan 1, 1978·Reviews of Physiology, Biochemistry and Pharmacology·W Kobinger
Oct 16, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·I C MedgettM J Rand
Oct 1, 1977·European Journal of Pharmacology·P B Timmermans, P A van Zwieten
Dec 1, 1977·Journal of Medicinal Chemistry·P B Timmermans, P A van Zwieten
Nov 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·P B TimmermansP A van Zwieten
May 1, 1973·British Medical Bulletin·L L Iversen
Aug 1, 1972·The Australian Journal of Experimental Biology and Medical Science·R L Hodge, S M Robinson
Jan 1, 1973·Circulation Research·O S SteinslandS M Kirpekar
Sep 1, 1968·European Journal of Pharmacology·J W Constantine, W K McShane

Related Concepts

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In Vitro [Publication Type]

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