Effects of Risperidone and Aripiprazole on Serum Levels of Prolactin, Testosterone and Estradiol in Female Patients with Schizophrenia

Drug Research
Xiao-Jia JiangDe-Wei Shang

Abstract

To evaluate the effects of treatment with risperidone and aripiprazole on serum prolactin, testosterone and estradiol levels in female patients with schizophrenia in China. In the retrospective study, Data were collected and included prolactin, testosterone and estradiol levels of 30 female patients with risperidone monotherapy. In the prospective study, Another 30 female schizophrenic patients were randomized to receive risperidone or adjunctive aripiprazole for six weeks. Serum prolactin, testosterone and estradiol levels were measured. Serum prolactin, testosterone and estradiol levels in both studies were significantly decreased after risperidone treatment compared with baseline (P<0.05), and prolactin levels remained at a high level. Serum prolactin levels in the adjunctive aripiprazole group were significantly decreased after treatment compared with baseline in the prospective study (P<0.05). Doses of 5 mg and 10 mg of adjunctive aripiprazole achieved the same efficacy at the end of treatment. Risperidone treatment decreased serum testosterone and estradiol levels. Adjunctive aripiprazole relieved hyperprolactinemia, but had no effect on testosterone or estradiol levels. Adjunctive aripiprazole at a dose of 5 mg is recomm...Continue Reading

Citations

May 7, 2020·Frontiers in Endocrinology·Samantha Alvarez-HerreraLenin Pavón
Oct 22, 2020·Brain Sciences·Samskruthi Madireddy, Sahithi Madireddy
Dec 22, 2020·Journal of Clinical Psychopharmacology·Tahir RahmanEric J Lenze
Feb 26, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Matthew M RusgisLeigh Anne Nelson
Feb 10, 2021·Current Opinion in Psychiatry·Bodyl A BrandIris E C Sommer
May 7, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Matthew M RusgisLeigh Anne Nelson

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