Effects of risperidone and olanzapine on remnant-like lipoprotein particle cholesterol (RLP-C) in schizophrenic patients.

Neuropsychiatric Disease and Treatment
Takahiko Nagamine

Abstract

Second generation antipsychotics are associated with the risk of metabolic disorders such as diabetes mellitus and hyperlipidemia. Remnant-like lipoprotein particles cholesterol (RLP-C) are a known risk factor for cardiovascular events. The present study was performed to determine possible differences in fasting blood RLP-C levels between schizophrenic patients treated with risperidone as compared to olanzapine. Patients on olanzapine had significantly higher RLP-C levels than those on risperidone (p < 0.01). In olanzapine-treated patients there was no abnormality in fasting blood glucose levels, but fasting insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR) were elevated. RLP-C levels were significantly correlated with plasma triglyceride concentrations in both the olanzapine- (p < 0.01) and risperidone-treated patients (p < 0.01). The regression line slope was greater for the olanzapine group, suggesting a greater influence of olanzapine on RLP-C. There was a significant correlation between RLP-C and HOMA-IR in the risperidone group (p < 0.01) but not in the olanzapine group (p = 0.80). These results suggest that blood glucose monitoring may not be sufficient to detect metabolic disorder and that ...Continue Reading

References

May 16, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·M OkazakiK Nakajima
Apr 3, 2002·Archives of General Psychiatry·John W NewcomerGregg Selke
Jul 18, 2002·Atherosclerosis·Hirofumi OhnishiKazuaki Shimamoto
Nov 13, 2004·Diabetes Research and Clinical Practice·Naoko TakayanagiRyuzo Kawamori

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Citations

Apr 26, 2014·PloS One·Maarten BakMarjan Drukker

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