Effects of rituximab treatment on the serum concentrations of vitamin D and interleukins 2, 6, 7, and 10 in patients with rheumatoid arthritis.

Biologics : Targets & Therapy
Eman HasanSunila George

Abstract

Rituximab, a monoclonal antibody that selectively targets CD20-positive B-lymphocytes, is used for the treatment of patients with rheumatoid arthritis (RA) with an inadequate response or tolerance to tumor necrosis factor inhibitors. The objective of this study was to investigate the effects of rituximab treatment on the serum concentrations of vitamin D, interleukin (IL) 2, IL-6, IL-7, and IL-10 in patients with rheumatoid arthritis (RA). Forty-five patients, aged 25-78 years, were enrolled into a cohort prospective study. All patients were treated with intravenous rituximab. Disease activity score-28 (DAS-28) and serum concentrations of rheumatoid factor (RF), C-reactive protein (CRP), anticyclic citrullinated peptide (anti-CCP), erythrocyte sedimentation rate (ESR), health assessment questionnaire (HAQ), vitamin D, ILs 2, 6, 7, and 10 were estimated in the patients before and after treatment with rituximab. DAS-28, HAQ score, and serum concentrations of CRP, RF, anti-CCP, IL-2, IL-6, IL-7, IL-10, and ESR significantly decreased after treatment. All 45 patients had vitamin D deficiency before treatment and this did not significantly change after treatment. However no significant association was found among serum vitamin D con...Continue Reading

References

Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·J M Lemire
Jan 20, 2004·Arthritis and Rheumatism·Linda A MerlinoUNKNOWN Iowa Women's Health Study
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Jun 15, 2007·Annals of the Rheumatic Diseases·Yoav ArnsonYehuda Shoenfeld
Aug 2, 2007·Annals of the Rheumatic Diseases·K H CostenbaderE Benito-Garcia
Oct 22, 2008·Arthritis Research & Therapy·Eva ZoldEdit Bodolay
Oct 22, 2008·Rheumatology·M Cutolo
Dec 10, 2008·The American Journal of Clinical Nutrition·Anne C LookerElizabeth A Yetley
Feb 14, 2009·Annals of the Rheumatic Diseases·M CutoloB Seriolo
Mar 26, 2009·Current Opinion in Rheumatology·Katherine P LiaoElizabeth W Karlson
Dec 25, 2009·Rheumatology International·Yolanda Braun-MoscoviciA Balbir-Gurman
Feb 6, 2010·The Journal of Clinical Endocrinology and Metabolism·John S Adams, Martin Hewison
Mar 20, 2010·Rheumatology International·Ayşe Dicle TurhanoğluCahit Ozer
Apr 16, 2010·The American Journal of Clinical Nutrition·Laura N AndersonJulia A Knight
Apr 20, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Sandra KarlssonDennis Larsson
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Aruna V KrishnanDavid Feldman
Jun 25, 2013·Mayo Clinic Proceedings·Arash Hossein-nezhad, Michael F Holick

❮ Previous
Next ❯

Citations

Aug 28, 2013·Nature Reviews. Nephrology·Agnes M Azimzadeh, Jonathan S Bromberg
Feb 2, 2013·Current Opinion in Rheumatology·Paul GatenbyAshwin Swaminathan

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
ESR

Software Mentioned

SPSS
Statistical Package for Social Sciences Software ( [ SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.