Effects of Rivaroxaban Therapy on ROTEM Coagulation Parameters in Patients with Venous Thromboembolism

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Krzysztof ChojnowskiJacek Treliński

Abstract

Rivaroxaban (Xarelto) does not require routine coagulation monitoring; however, in certain clinical situations (overdose, drug accumulation, urgent surgery) measurement of its plasma concentration is highly recommended. Currently, there is no single hemostasis test that shows a direct correlation between rivaroxaban plasma levels and anticoagulant efficacy. This study was intended to assess the value of ROTEM in determining rivaroxaban administration. Thirteen patients with venous thromboembolism and 13 healthy volunteers were compared with regard to certain ROTEM parameters and anti-FXa activity. The tests were done before the administration of 20 mg rivaroxaban (i.e. 24 h after previous administration) and 2.5 h afterwards. The study group demonstrated residual activity of rivaroxaban in plasma (20 ± 11.3 ng/mL) 24 h following the previous administration, which did not cause marked changes in clotting assays compared to controls. In the group, 2.5 h after rivaroxaban administration, prolongation of PT (PTratio 1.51 ± 0.22), APTT (APPTratio: 1.30 ± 0.14) and ROTEM CT (CTratio - EXTEM: 2.45 ± 1.06, CTratio - 1.32 ± 0.21) were observed. The cut-off values for particular tests were created to determine if the patient had achieved...Continue Reading

Citations

Dec 7, 2018·Journal of Thrombosis and Thrombolysis·Syed MahamadMichelle Sholzberg
Oct 12, 2018·European Journal of Anaesthesiology·Claire PailleretCharles M Samama
Apr 11, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V F de ArandaJ C de Campos Guerra
Oct 3, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Elias KyriakouArgirios E Tsantes
Feb 18, 2017·Clinical and Experimental Medicine·Christian SchoergenhoferPetra Jilma-Stohlawetz
Oct 6, 2017·International Journal of Laboratory Hematology·L SeyveR Marlu
Jun 16, 2021·Seminars in Thrombosis and Hemostasis·Barbora KorpallováMarián Mokáň

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