Effects of ropivacaine combined with morphine at 0.15 and 0.2 mg kg(-1) in bitches undergoing epidural anesthesia

Acta Cirúrgica Brasileira
Verônica Batista de AlbuquerqueValéria Nobre Leal de Souza Oliva

Abstract

To investigate cardiorespiratory effects and serum concentration of ropivacaine combined with morphine at different doses. Sixteen healthy adult female dogs weighting 9.8 ± 4.1 kg were included in the study. Twenty minutes after being premedicated with acepromazine and midazolam, the animals were randomly assigned to receive an epidural injection according to each group: RM0.15 = ropivacaine + morphine (0.15 mg kg(-1)) and RM0.2 = ropivacaine + morphine (0.2 mg kg(-1)). Variables recorded consisted of: heart rate and cardiac rhythm, respiratory rate, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, systolic, mean and diastolic arterial pressures, serum cortisol, plasma ropivacaine and morphine. SAP, MAP and DAP were significantly increased at TPR in RM0.15 but returned to normal values at the end of the procedure. Arterial pH was decreased in T30 and TESu in both groups and also returned to acceptable ranges at TR. Both PaO2 and PaCO2 were increased along the duration period of the epidural blockade (T30 and TESu) and returned to acceptable values at TR. Serum cortisol was lower at TB, T30 and TR when compared to TESu. The procedures were performed safely and minimal changes in cardiovascula...Continue Reading

References

Mar 1, 1971·Anesthesia and Analgesia·C A DiFazio, P Y Chen
Apr 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A BarakaA Sibai
Mar 13, 2001·The Veterinary Journal·R S Jones
Jul 30, 2005·Journal of Veterinary Pharmacology and Therapeutics·B KuKanichM G Papich
Jun 13, 2006·Veterinary Anaesthesia and Analgesia·Sithembile SibandaChristopher R Bellenger
Oct 29, 2008·The Veterinary Clinics of North America. Small Animal Practice·Alexander Valverde
Feb 1, 2004·Revista brasileira de anestesiologia·Neuzimar de Souza Freire SilvaAdriana Machado Issy

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Citations

Dec 7, 2016·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Hou-Chuan LaiZhi-Fu Wu

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