PMID: 11933119Apr 5, 2002Paper

Effects of Rosa canina fruit extract on neutrophil respiratory burst

Phytotherapy Research : PTR
D A Daels-RakotoarisonJ-C Cazin

Abstract

Respiratory burst leads polymorphonuclear neutrophils (PMN) to produce reactive oxygen species (ROS) such as superoxide anions (O(2)(o-)), hypochlorous acid (HOCl) and hydrogen peroxide (H(2)O(2)) which may possess deleterious effects for the organism. Rosa canina fruits are well known to contain a large amount of vitamin C which is antioxidant. This study was focused on the polyphenolics contained in rose hips to evaluate their antioxidative properties. We prepared a rose hip extract deprived of vitamin C. The extract contained mainly phenolics such as proanthocyanidins and flavonoids. We investigated its effects directly against (O(2)(o-)), HOCl and H(2)O(2) and investigated its effects on isolated PMN. For that, in vitro inflammatory conditions were reproduced by stimulating PMN with stimuli having different transductional pathways, in order to determine a possible mechanism of action. The results showed that the extract can inhibit ROS tested in acellular and cellular systems. The IC(50) obtained were 5.73 mg/L, 1.33 mg/L and 2.34 mg/L respectively for (O(2)(o-)), HOCl and H(2)O(2) in acellular experiments. For cellular experiments, the IC(50) were quite similar. Thus, the extract did not present an effect on PMN metabolism...Continue Reading

References

Jan 1, 1992·The British Journal of Nutrition·H Hemilä
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Sep 1, 1982·The Journal of Clinical Investigation·S J WeissM Wei
Aug 1, 1994·Planta medica·T BahorunM Pinkas
Feb 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A CabanisJ C Cazin
Feb 1, 1996·Journal of Natural Products·E Haslam
Dec 1, 1992·Planta medica·Y MoumouM Pinkas

❮ Previous
Next ❯

Citations

Sep 30, 2006·Digestive Diseases and Sciences·A HåkanssonB Jeppsson
Mar 2, 2005·Lipids·Sebastian SchafferFrancesco Visioli
Oct 12, 2010·Pharmacognosy Magazine·Hasan Kılıçgün, Dehen Altıner
May 12, 2012·Oxidative Medicine and Cellular Longevity·Milan CizAntonin Lojek
Jan 17, 2016·Journal of Food Science·Vlasta CunjaValentina Schmitzer
Mar 23, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Bente KirkeskovJens Rikardt Andersen
Oct 13, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S N WillichK Winther
Aug 19, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E M WenzigR Bauer
Jul 3, 2004·The Journal of Pharmacy and Pharmacology·Omidreza FiruziLuciano Saso
Oct 27, 2009·Phytotherapy Research : PTR·Melainie CameronSigrun Chrubasik
Apr 4, 2008·Phytotherapy Research : PTR·Cosima ChrubasikSigrun Chrubasik
Jul 27, 2010·Phytotherapy Research : PTR·Jacqueline I KeenanAlison J Wallace
Nov 16, 2011·Journal of the Science of Food and Agriculture·Vesna T TumbasLars Gille
Jul 22, 2014·Phytotherapy Research : PTR·S Chrubasik-HausmannU Müller-Ladner
Apr 9, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·T Benie, M L Thieulant
Jan 6, 2006·Phytotherapy Research : PTR·C ChrubasikS Chrubasik
Jul 21, 2011·Journal of Ethnopharmacology·Francesca LattanzioEster Speroni
Jul 22, 2010·Pharmaceutical Biology·Gisèle Kouakou-SiransyFrançois Bailleul
Jun 13, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ernesto DalliJosé Francisco Sotillo
Mar 17, 2010·Plant Physiology and Biochemistry : PPB·Alessandro LentiniSimone Beninati
Aug 7, 2008·Biotechnology Advances·Adam Matkowski
Apr 2, 2019·Current Pharmaceutical Design·Mehrnoosh SedighiMahmoud Rafieian-Kopaei
Dec 17, 2016·Nutrition & Metabolism·Michele CavaleraCecilia Holm
Jul 15, 2009·Revista brasileira de enfermagem·Joyce Silva dos SantosIvone Kamada
Oct 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Ulrika AnderssonCecilia Holm
Jan 17, 2020·Pakistan Journal of Biological Sciences : PJBS·Fatemeh KarimimojahedAlireza Nourian
Nov 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anca UngurianuRucsandra Dǎnciulescu-Miulescu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.