Effects of rosiglitazone (a peroxysome proliferator-activated receptor gamma agonist) on the blood pressure and aortic structure in metabolically programmed (perinatal low protein) rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Thiago da Silva TorresCarlos Alberto Mandarim-de-Lacerda

Abstract

This study investigated the effects of rosiglitazone on nutritionally programmed chronic disease, with a focus on blood pressure (BP) and aortic wall structural remodeling. Wistar pregnant rats were fed one of two diets: a normal protein diet (19% protein; NP rats) or low-protein diet (5% protein; LP rats). Male offspring at 3 months of age were randomly divided into four groups: NP offspring treated with rosiglitazone (NPR); untreated NP offspring (NP); LP offspring treated with rosiglitazone (LPR); untreated LP offspring (LP). Rosiglitazone was administered at a dose of 5 mg/kg/d until 6 months of age. BP was elevated in LP offspring. Rosiglitazone reduced BP beginning in the first week of treatment in the LPR offspring. The insulin sensitivity was increased in LP offspring, and was not altered by rosiglitazone. LP offspring exhibited a 40% reduction in the amount of elastic fibers in the aorta wall compared with NP offspring (p < 0.01), and the quantity of elastic fibers was not altered by rosiglitazone. The smooth muscle cells, elastic lamellae, circumferential wall tension (CWT) and tensile stress (TS) were increased in LP offspring, indicating increased blood flow in the aorta. Rosiglitazone reduced both CWT and TS by 30%...Continue Reading

References

Aug 1, 1996·Comparative Biochemistry and Physiology. Part A, Physiology·S C Langley-Evans
Jul 23, 1998·Hypertension·M E SafarE D Frohlich
Jan 26, 2002·British Medical Bulletin·S E Ozanne
Jan 1, 1956·Stain Technology·H M FULLMER, R D LILLIE
Nov 8, 2003·Anais Da Academia Brasileira De Ciências·Carlos A Mandarim-de-Lacerda
Nov 14, 2003·Cardiovascular Research·Maria do Carmo Pinho FrancoFrida Zaladek Gil
Jul 15, 2004·Seminars in Nephrology·Ming-Sheng ZhouLeopoldo Raij
Dec 30, 2004·Journal of Molecular and Cellular Cardiology·Yasuhiro MaejimaMitsuaki Isobe
May 20, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Mark C Granberry, Vivian A Fonseca
Jun 29, 2005·Diabetes·Catherine Gallou-Kabani, Claudine Junien
Aug 30, 2005·Diabetes Research and Clinical Practice·Roberto NegroHaslinda Hassan
Sep 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Karim BenkiraneErnesto L Schiffrin
Jan 18, 2006·Hypertension·Kambiz Zandi-NejadBarry M Brenner
Feb 2, 2006·Annals of Medicine·Enzo Bonora
Apr 4, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Behzad MolaviJ L Mehta
Jun 3, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C YzydorczykA M Nuyt
Jun 13, 2006·Vascular Pharmacology·David V ErbeJames F Tobin
Aug 8, 2006·Life Sciences·Karla Maria Pereira PiresCarlos Alberto Mandarim-de-Lacerda
Jan 16, 2007·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Emily A Van VréWillem J Van der Giessen
May 23, 2007·The New England Journal of Medicine·Steven E Nissen, Kathy Wolski
Jun 7, 2007·The New England Journal of Medicine·Philip D HomeUNKNOWN RECORD Study Group
Jun 19, 2007·Lancet·Ronald L Krall

❮ Previous
Next ❯

Citations

Jan 8, 2013·European Journal of Nutrition·Diana F Serapiao-MoraesTatiane S Faria
Dec 30, 2015·International Journal of Molecular Sciences·You-Lin TainJulie Y H Chan
May 8, 2010·Pathology, Research and Practice·Thiago da Silva TorresCarlos Alberto Mandarim-de-Lacerda
Sep 25, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Geraldo de Oliveira Silva-JuniorCarlos Alberto Mandarim-de-Lacerda
Jun 3, 2021·Biomedicines·Chien-Ning Hsu, You-Lin Tain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.