PMID: 2497492Jan 1, 1989Paper

Effects of route of administration of ethanol on high-speed reaction time in young and old rats

Psychopharmacology
W W SpirdusoT Schallert

Abstract

The blood ethanol concentrations (BECs) and reactive capacity of young (8 months) and old (24 months) male Fischer 344 rats were compared at 5, 10, 20, 45, 65, and 90 min following the administration of ethanol (EtOH). The time-dependent effects of intragastric intubation (IG; 3 g/kg) and intraperitoneal injection (IP; 1.5 g/kg) of EtOH (20% w/v) were determined. Subsequent to IG delivery, BECs rose most rapidly within the first 20 min, but did not reach peak levels until 90 min for both young (240 mg/dl) and old rats (250 mg/dl). Following IP injections, BECs escalated within 5 min to 250 mg/dl in the young, to 175 mg/dl in the old, and declined gradually to a stabilized value of 150 mg/dl (young) and 130 mg/dl (old). The old rats never achieved the high BECs seen in the young. Reactive capacity, a measure of auditory/visual reaction time, was inversely related to BECs. As BECs (IP) declined, performance improved at a similar rate in both age groups, although the old rats' performance was more impaired than that of the young. However, BEC per se was not an adequate predictor of reactive capacity. When EtOH was delivered by IG so that BECs remained high for long periods of time, reactive capacity was far less impaired compared ...Continue Reading

References

Jan 1, 1979·Drug and Alcohol Dependence·B Tabakoff, R F Ritzmann
Jul 1, 1987·Journal of Pharmaceutical Sciences·S Wanwimolruk, G Levy
Jan 1, 1980·Revue d'élevage et de médecine vétérinaire des pays tropicaux·J EspinasseM Savey
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·H K Hahn, R E Burch
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·W G Wood, H J Armbrecht
Jan 1, 1958·Acta Pharmacologica Et Toxicologica·F LUNDQUIST, H WOLTHERS
Feb 1, 1961·Canadian Journal of Biochemistry and Physiology·C CZAJA, H KALANT

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Citations

Jul 1, 1996·Pharmacology, Biochemistry, and Behavior·D E SpiersP A Eichen
Nov 11, 1998·Neuroscience and Biobehavioral Reviews·A Blokland
Jan 30, 2013·Experimental and Clinical Psychopharmacology·Jeffrey S SteinGregory J Madden
May 26, 2006·Journal of Clinical and Experimental Neuropsychology·Stuart W S MacDonaldDavid Bunce
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H Y WangE Friedman
Aug 26, 2000·Behavioral Neuroscience·Tyler W FeolaJerry B Richards
Jul 22, 2015·Psychopharmacology·Kelvin Quiñones-LaracuenteGregory J Quirk
Jan 24, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Sarah E Cavanaugh
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Adam J WoodsRonald A Cohen
Jun 30, 2007·Neuroscience and Biobehavioral Reviews·Chuan-Sheng ZhaoJukka Jolkkonen

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