Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans.

Nature Communications
Daniel MartinsYannis Paloyelis

Abstract

Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally? We address this question by contrasting two methods of intranasal administration (a standard nasal spray, and a nebulizer expected to improve OT deposition in nasal areas putatively involved in direct nose-to-brain transport) to intravenous administration in terms of effects on regional cerebral blood flow during two hours post-dosing. We demonstrate that OT-induced decreases in amygdala perfusion, a key hub of the OT central circuitry, are explained entirely by OT increases in systemic circulation following both intranasal and intravenous OT administration. Yet we also provide robust evidence confirming the validity of the intranasal route to target specific brain regions. Our work has important translational implications and demonstrates the need to carefully consider the method of administration in our efforts to engage specific central oxytocinergic targets for the treatment of neuropsychiatric disorders.

References

Jun 17, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D R ThedensD G Nishimura
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric HollanderSerge Mosovich
Mar 1, 2003·Frontiers in Neuroendocrinology·John A RussellAlison J Douglas
Jul 17, 2004·The European Journal of Neuroscience·Grégoire LevasseurMonique Caillol
Jul 30, 2005·Neuromolecular Medicine·Bronwen MartinStuart Maudsley
Nov 25, 2005·Current Drug Delivery·Tushar K VyasAmbikanandan Misra
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter KirschAndreas Meyer-Lindenberg
Aug 15, 2006·Biological Psychiatry·Eric HollanderStacey Wasserman
Oct 3, 2006·Brain and Language·Carrie T Drake, Costantino Iadecola
Jul 20, 2007·Biochemical Society Transactions·B Chini, M Manning
Aug 21, 2007·Biological Psychiatry·Mohammed R MiladScott L Rauch
Nov 11, 2008·Nature Biotechnology·Mark R Prausnitz, Robert Langer
Mar 28, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Heikki V HuikuriGian Domenico Pinna
Mar 24, 2010·Schizophrenia Bulletin·Andrew J RosenfeldL Fredrik Jarskog
Dec 21, 2010·Trends in Cognitive Sciences·Amit EtkinRaffael Kalisch
Jan 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshiyuki HiranoAfonso C Silva
Feb 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Danny J J WangJohn A Detre
Feb 18, 2011·Current Problems in Dermatology·Christoph BitterChristian Surber
Mar 25, 2011·Psychoneuroendocrinology·Elayne MacDonaldAvril J Cauchi
Oct 1, 2011·Stroke; a Journal of Cerebral Circulation·Kate KarelinaA Courtney DeVries
Nov 29, 2011·Advanced Drug Delivery Reviews·Jeffrey J Lochhead, Robert G Thorne
Dec 27, 2011·Hormones and Behavior·Patricia S Churchland, Piotr Winkielman
Feb 4, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lisbeth Illum
Mar 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Per G DjupeslandJohn C Messina
Mar 26, 2013·Journal of Magnetic Resonance Imaging : JMRI·Binu P ThomasHanzhang Lu
Apr 12, 2013·Journal of Neuroendocrinology·S M KagerbauerR Landgraf
Nov 19, 2013·Brain Research·Simon L EvansBruno B Averbeck
Feb 1, 2014·Journal of Clinical and Experimental Neuropsychology·Carla RuisMartine J E van Zandvoort
Apr 10, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David C AlsopGreg Zaharchuk
Dec 17, 2014·Biological Psychiatry·Yannis PaloyelisMatthew A Howard

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Citations

Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Nina MarshRené Hurlemann
Sep 12, 2020·Pharmacological Reviews·C Sue CarterMarcy A Kingsbury
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Inbar SchlachetAlejandro Sosnik
Dec 12, 2020·Physiology & Behavior·Juan Pablo DamiánElize van Lier
Jan 17, 2021·Communications Biology·Daniel MartinsYannis Paloyelis
Dec 15, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kaat AlaertsSylvie Bernaerts
Jan 26, 2021·Drug Delivery and Translational Research·Lea-Adriana KellerAndreas Popp
Jun 9, 2020·Pharmacology & Therapeutics·Samata R SharmaFrank I Tarazi
Mar 16, 2021·Current Behavioral Neuroscience Reports·Marilyn HortaNatalie C Ebner
Oct 20, 2020·Frontiers in Neuroscience·Erin C McKay, Scott E Counts
Mar 26, 2021·ELife·Ortal Shimon-RazRuth Feldman
May 3, 2021·BMC Neuroscience·Stanislav M CherepanovHaruhiro Higashida
Jun 12, 2021·Frontiers in Neuroscience·Hirofumi KurokawaFumio Ohtake
Jun 9, 2021·Social Cognitive and Affective Neuroscience·Shiu F WongMark A Ellenbogen
Aug 11, 2021·Pharmaceutics·Vimala N BharadwajDavid C Yeomans
Jul 9, 2021·British Journal of Pharmacology·Ben HoughtonAlexis Bailey
Sep 10, 2021·The European Journal of Neuroscience·Philippe C HabetsOnno C Meijer
Nov 4, 2021·Drug Delivery and Translational Research·Mireya L Borrajo, María José Alonso

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Software Mentioned

ggplot2
R
MATLAB
SPSS
FSL
SPM12
ASAP ( Automatic Software for ASL processing )
FMRIB Software Library ( FSL )
house
Kubios HRV

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