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Effects of S-1389 (711389-S), a new antiarrhythmic agent, on the conduction in perfused guinea pig hearts

Japanese Journal of Pharmacology

Dec 1, 1989

M NinomiyaM Ueda

Abstract

In the His bundle and ventricular electrograms of Langendorff-perfused guinea pig hearts driven at a cycle length of 450 or 700 msec, S-1389 (711389-S), a new antiarrhythmic agent, above 3 x 10(-7) or 10(-6) M increased the basal conduction times in the following order: His-Purkinje sys...read more

Mentioned in this Paper

Refractory Period, Electrophysiological
Cardiac Depressants
Left Bundle Branch of His
Perfusion
Propanolamines
In Vitro [Publication Type]
Structure of Atrioventricular Node
Metazoa
1-(1-(2-(3-isopropylamino-2-hydroxypropoxy)-3,6-dichlorophenyl)vinyl)-1H-imidazole
NODAL
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Effects of S-1389 (711389-S), a new antiarrhythmic agent, on the conduction in perfused guinea pig hearts

Japanese Journal of Pharmacology

Dec 1, 1989

M NinomiyaM Ueda

PMID: 2615048

DOI: 10.1254/jjp.51.555

Abstract

In the His bundle and ventricular electrograms of Langendorff-perfused guinea pig hearts driven at a cycle length of 450 or 700 msec, S-1389 (711389-S), a new antiarrhythmic agent, above 3 x 10(-7) or 10(-6) M increased the basal conduction times in the following order: His-Purkinje sys...read more

Mentioned in this Paper

Refractory Period, Electrophysiological
Cardiac Depressants
Left Bundle Branch of His
Perfusion
Propanolamines
In Vitro [Publication Type]
Structure of Atrioventricular Node
Metazoa
1-(1-(2-(3-isopropylamino-2-hydroxypropoxy)-3,6-dichlorophenyl)vinyl)-1H-imidazole
NODAL

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