PMID: 1206811Aug 1, 1975Paper

Effects of S-8527 (1, 1-bis (4'-(1"-carboxy-1"-methylpropoxy) phenyl) cyclohexane), a new hypolipidemic compound, on platelet aggregation, adhesiveness and blood coagulation in rats

Japanese Journal of Pharmacology
K Suzuki

Abstract

Effects of S-8527 (1,1-bis[4'-(1"-carboxy-1"-methylpropoxy) phenyl] cyclohexane) on platelet aggregation, adhesiveness and blood coagulation were examined in rats. In animals maintained on a semisynthetic diet containing sucrose (62%) as the only carbohydrate source, platelet adhesiveness increased as compared with that in rats fed a normal chow pellet. Under these experimental conditions, oral dose of S-8527 (30-300 mg/kg) for 14 days decreased platelet adhesiveness and ADP-induced platelet aggregation, but did not decrease collagen-induced platelet aggregation. S-8527 also showed a slight but significant increase of R value of thrombelastograph. In rats which were fed a normal chow pellet oral dose of S-8527 for 14 days did not significantly affect the several tests of platelet function and blood coagulation. These results suggest that S-8527 normalizes the platelet function in a hyper-adhesive state, but does not affect the platelet function in a normal state.

References

Feb 21, 1974·The New England Journal of Medicine·A C CarvalhoR S Lees
Jun 1, 1971·The American Journal of Cardiology·J Hampton
Jun 1, 1974·Japanese Journal of Pharmacology·K SuzukiH Nakatani
Jan 1, 1973·Annual Review of Pharmacology·R J Havel, J P Kane
Jul 1, 1973·Atherosclerosis·K TokiS Aono
Dec 15, 1973·Biochemical Pharmacology·J F Mustard, M A Packham
Apr 1, 1966·The American Journal of Clinical Nutrition·N A KaufmannY Stein
Jan 15, 1968·Life Sciences·A M Cohen, A Teitelbaum
Dec 1, 1965·American Journal of Clinical Pathology·B S BullG Brecher
Jan 1, 1967·The American Journal of the Medical Sciences·H J DayL A Soloff
Nov 1, 1967·The Journal of Physiology·D C Mills, G C Roberts
Feb 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·O W PORTMAND BRUNO
Mar 1, 1962·Archives of Internal Medicine·M J ALBRINK
Jun 1, 1965·Annals of Internal Medicine·P T KUO, D R BASSETT
Jan 1, 1948·The Journal of Pathology and Bacteriology·J B DUGUID

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Indian Journal of Physiology and Pharmacology
S SudhirR D Budhiraja
International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
M GuptaM M Mittal
© 2022 Meta ULC. All rights reserved