Effects of S-nitroso-N-acetylcysteine on contractile function of reperfused skeletal muscle

The American Journal of Physiology
L E ChenJ R Urbaniak

Abstract

The ultimate goal of replantation and microsurgical reconstructive operations is to regain or improve impaired function of the tissue. However, the data related to the influence of NO on tissue function are limited. This study evaluated the effects of the NO donor S-nitroso-N-acetylcysteine (SNAC) on contractile function of skeletal muscle during reperfusion. Forty-nine rats were divided into six groups. The extensor digitorum longus (EDL) muscles in groups I and II were not subjected to ischemia-reperfusion but were treated with a low (100 nmol/min) or high (1 mumol/min) dose of SNAC. In groups III-V, the EDL underwent 3 h of ischemia and 3 h of reperfusion and was also treated with low (100 nmol/min) or high doses (1 or 5 mumol/min) of SNAC. Group VI was a phosphate-buffered saline (PBS)-treated control group. Twenty additional animals were used to document systemic effects of SNAC and PBS only. SNAC or PBS was infused for 6.5 h, beginning 30 min before ischemia and continuing throughout the duration of reperfusion. Contractile testing compared the maximal twitch force, isometric tetanic contractile forces, fatigue, and fatigue half time of the experimental EDL and the contralateral nontreated EDL. The findings indicate that ...Continue Reading

References

Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Nov 1, 1992·Journal of Applied Physiology·M B ReidM S West
Dec 31, 1991·Biochemical and Biophysical Research Communications·G M RubanyiL H Botelho
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Oct 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·D T EngelmanD K Das
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·Z G ZhangU Förstermann
Dec 8, 1994·Nature·L KobzikJ S Stamler
Jan 1, 1994·Microsurgery·L K KnoxW A Morrison
Jun 15, 1995·Biochemical and Biophysical Research Communications·L KobzikJ S Stamler
Jul 1, 1994·The Journal of Surgical Research·H AbdihD J Bouchier-Hayes
Feb 1, 1994·Annals of Internal Medicine·C J LowensteinS H Snyder
Jul 15, 1993·Biochemical and Biophysical Research Communications·V C PatelR G Woolfson
May 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M P BolognesiJ R Urbaniak

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Citations

Aug 15, 2001·American Journal of Physiology. Cell Physiology·W N QiJ R Urbaniak
Dec 31, 2002·Journal of Applied Physiology·Li ZhangJames R Urbaniak
Oct 17, 2008·Physiological Reviews·Scott K Powers, Malcolm J Jackson
Feb 1, 2018·International Journal of Molecular Sciences·Tingyang ZhouLi Zuo
Jan 12, 2001·Physiological Reviews·J S Stamler, G Meissner
Aug 16, 2000·American Journal of Physiology. Cell Physiology·T J Koh, J G Tidball
Jun 8, 2004·Journal of Applied Physiology·Wen-Ning QiJames R Urbaniak
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R K KudejS F Vatner

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