Effects of SA237, a humanized anti-interleukin-6 receptor monoclonal antibody, on pre- and postnatal development in cynomolgus monkey

Birth Defects Research
Ryuichi KatagiriShuichi Chiba

Abstract

SA237 is a humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody in which the constant and variable regions have been engineered for a longer plasma half-life. According to literature, blocking of IL-6 related functions could have an influence on pregnancy sustainment, development of the immune system, and brain growth. SA237 effects on dams, embryo-fetal development, parturition and postnatal development were investigated in an enhanced pre- and postnatal development study, in which SA237 was subcutaneously administered to pregnant cynomolgus monkeys at dose levels of 2 or 50 mg/kg once weekly from gestation day 20 until parturition. Infant development, including immune function and learning ability tests, was comprehensively assessed at multiple examinations until approximately 10 months after birth. SA237 plasma concentrations were almost equivalent between dams and their infants and dropped throughout the postnatal period, pharmacologically relevant exposure was maintained for 147 days after birth at 50 mg/kg. Because the binding of SA237 to IL-6R inhibited IL-6R-mediated clearance of IL-6, serum IL-6 increased in dams and infants. However, there were no SA237-related adverse effects on dams, embryos, fetuses, o...Continue Reading

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T HiranoT Kishimoto
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S SuematsuT Kishimoto
Jun 1, 1983·Japanese Journal of Medical Science & Biology·K FujimotoS Honjo
Jan 1, 1997·Annual Review of Immunology·T Taga, T Kishimoto
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Sep 1, 2005·Clinical Reviews in Allergy & Immunology·Tetsuya Taga, Shinji Fukuda
May 19, 2006·Journal of Leukocyte Biology·Stefan Rose-JohnSimon A Jones
Feb 22, 2007·Nature Reviews. Neuroscience·Sylvian BauerPaul H Patterson
Oct 31, 2008·Molecular Biology of the Cell·Omedul IslamKlaus Heese
Jan 14, 2009·The Journal of Experimental Medicine·Oliver DienzMercedes Rincon
Mar 14, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Nancy G WehnerJanet Clarke
Dec 22, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Gary J ChellmanGerhard F Weinbauer
Feb 18, 2010·Protein Engineering, Design & Selection : PEDS·T IgawaK Hattori
Apr 23, 2010·International Immunology·Tadamitsu Kishimoto
Jun 29, 2010·European Journal of Immunology·Akihiro Kimura, Tadamitsu Kishimoto
Jul 9, 2010·Journal of Leukocyte Biology·J S Silver, C A Hunter
Oct 12, 2010·International Journal of Toxicology·Pauline L Martin, Gerhard F Weinbauer
Oct 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anu VaidyanathanJoseph C Beyer
Jan 25, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Gerhard F WeinbauerCraig M Luetjens
Feb 22, 2012·Critical Reviews in Toxicology·John M DeSessoMark E Hurtt
Jul 7, 2012·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Takayuki SakuraiLutz Müller
Jul 24, 2012·Journal of Reproductive Immunology·Jelmer R PrinsSarah A Robertson
Jul 25, 2013·International Journal of Molecular Sciences·Alyaa Mousa, Moiz Bakhiet
Oct 1, 2013·Pharmacology & Therapeutics·Xin YaoYihong Yao
Jan 7, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Christopher J BowmanSimon Chivers
Apr 23, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Graeme J MoffatGary J Chellman
Sep 5, 2014·Science Translational Medicine·Amir ArdeshirDennis J Hartigan-O'Connor
Sep 13, 2015·Regulatory Toxicology and Pharmacology : RTP·C RoseG F Weinbauer
Jun 28, 2016·Seminars in Arthritis and Rheumatism·Maria HoeltzenbeinMonika Østensen
Jul 7, 2016·Immunotherapy·Toshio TanakaTadamitsu Kishimoto

❮ Previous
Next ❯

Citations

Apr 21, 2020·Expert Review of Neurotherapeutics·Mattia RossoTanuja Chitnis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.