PMID: 6398298Jan 1, 1984Paper

Effects of saccharin and urine on the decomposition of N-nitrosomethylurea

IARC Scientific Publications
C T Miller

Abstract

Addition of either saccharin or rat urine to aqueous N-methyl-N-nitrosourea (MNU) caused concentration-dependent loss of the ultraviolet absorption of MNU. The shapes of the absorption spectra of the residual MNU products were different and characteristic of either saccharin (flat-sided) or urine (symmetrical) as reaction matrix. In the presence of urine from rats fed 2.5% saccharin in the diet, the flat-sided curve characteristic of MNU-saccharin products was always observed. Further, the half-life of the MNU products in urine from saccharin-treated rats was shorter than the half-life observed in control urine, suggesting that saccharin ingestion might alter both the nature and rate of MNU decomposition in vivo. A molecular hypothesis for the mechanism of the MNU/saccharin interaction is proposed.

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