PMID: 2118808Aug 28, 1990Paper

Effects of salmon oil and corn oil on plasma lipid level and hepato-biliary cholesterol metabolism in rats

Biochimica Et Biophysica Acta
M ChautanH Lafont

Abstract

The aim of this work was to compare the effects of n-3 and n-6 fatty acids on plasma lipid level and hepato-biliary cholesterol metabolism by studying rats fed semi-synthetic diets enriched with either 10% salmon oil, 10% corn oil, or a blend of 6% corn oil and 4% salmon oil. After 4 weeks of feeding, a drop in plasma lipid level was noted in the salmon oil group in comparison to the control group, whereas no change was observed in the corn oil group. An increase in production of cholesterol ester by the liver was recorded in the salmon oil group with a marked enhancement in acyl-CoA:cholesterol acyltransferase (ACAT: EC 2.3.1.26) activity and hepatic cholesterol concentration. Corn oil did not affect either ACAT activity or hepatic cholesterol storage. All bile parameters (flow, bile salts, phospholipids, cholesterol) increased in the salmon oil group, but the molar ratio of cholesterol participation in the bile secretion decreased. These changes in bile composition, as well as in hepatic metabolism of cholesterol, may help to explain the hypolipidemia following the intake of fish oil.

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Citations

Jan 26, 1993·European Journal of Pharmacology·K MizuguchiY Saito
Jun 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M LutzG Ruiz
Nov 13, 2004·The Journal of Nutritional Biochemistry·K NageswariV P Menon
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Ishtiaq MahmudMichio Hashimoto
Sep 19, 2007·Journal of Nutritional Science and Vitaminology·Junichi MatsumotoKiyoshi Ebihara
Mar 10, 2004·The British Journal of Nutrition·Pujitha P de SilvaSukhinder Kaur Cheema
Nov 1, 1996·The British Journal of Nutrition·A C BeynenM B Katan
Sep 1, 1992·The British Journal of Nutrition·T A Sanders, S Sandaradura
Dec 1, 1994·The American Journal of Physiology·F BenhiziaS Griglio
May 6, 2003·The Journal of Nutrition·Isabelle DemontyHélène Jacques

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