Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice.

Infection and Immunity
H C Lima, R Titus

Abstract

The saliva of the sand fly vector of leishmaniasis significantly enhanced infection with doses of >10(4) Leishmania braziliensis parasites in BALB/c mice. With a dose of 10(7) L. braziliensis parasites, 60 to 70% of the mice developed lifetime infections. Mice infected with L. braziliensis plus saliva produced two- to threefold more interleukin-4 than did mice infected with L. braziliensis alone. Treatment with a neutralizing anti-interleukin-4 antibody abrogated the effects of the saliva.

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Citations

Mar 25, 2000·Memórias do Instituto Oswaldo Cruz·G M Santos-GomesP Abranches
Sep 21, 2004·Parasitology Research·Tatiani Uceli MaioliLuís Carlos Crocco Afonso
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