Effects of sappanchalcone on the cytoprotection and anti-inflammation via heme oxygenase-1 in human pulp and periodontal ligament cells

European Journal of Pharmacology
Gil-Saeng JeongYoun-Chul Kim

Abstract

Sappanchalcone has been demonstrated to possess several biological effects. However, the molecular mechanism underlying these effects is not fully understood. In this study, we examined the effects of sappanchalcone on hydrogen peroxide (H(2)O(2))-induced cytotoxicity using human dental pulp (HDP) cells, and lipopolysaccharide (LPS)-induced inflammation using human periodontal ligament (HPDL) cells. Sappanchalone concentration proportionately increased heme oxygenase (HO)-1 protein expression and enzyme activity in both HDP and HPDL cells. It also protected HDP cells from H(2)O(2)-induced cytotoxicity and reactive oxygen species production. The cytoprotective effect of sappanchalcone was nullified by HO-1 inhibitor, Tin protoporphyrin (SnPP). Sappanchalcone is seen to inhibit LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), interlukine-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interlukine-6 (IL-6) and interlukine-12 (IL-12) release in addition to inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in HPDL cells. SnPP, a specific inhibitor of HO-1, partly blocked sappanchalcone mediated suppression of inflammatory mediator production, in LPS-stimulated HPDL cells. HDP and...Continue Reading

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Citations

Jun 27, 2013·Molecular Neurobiology·Dah-Yuu LuYueh-Hsiung Kuo
Jun 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing-Yuan ChuangDah-Yuu Lu
Jul 15, 2015·Archives of Oral Biology·Diana G SoaresCarlos A de Souza Costa
Oct 4, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Young-Man LeeEun-Cheol Kim
Jan 16, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Dong-Sung LeeYoun-Chul Kim
Sep 14, 2011·European Journal of Pharmacology·Gil-Saeng JeongYoun-Chul Kim
Aug 16, 2016·Molecular Nutrition & Food Research·Si Qin, De-Xing Hou
Nov 12, 2014·Chemical Research in Toxicology·Sarandeep S S BoyanapalliAh-Ng Tony Kong
Dec 3, 2013·Natural Product Reports·Hemant KumarDong-Kug Choi
Feb 21, 2019·International Journal of Oral Science·Alexandra StähliReinhard Gruber
Jul 4, 2019·Current Pharmaceutical Design·Ana PaunkovGerasimos P Sykiotis
Nov 2, 2019·Cytokine·Mohammad M Y KhorasaniHossein Khorramdelazad
Feb 10, 2021·Expert Opinion on Therapeutic Targets·Ranjana BhandariAnurag Kuhad

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