Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes

Diabetes, Obesity & Metabolism
S M PoucherS P Vickers

Abstract

We examined the effects of the oral dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin on glycaemic control and pancreatic β-cell mass and morphology in a mouse model of type 2 diabetes mellitus (T2DM). Male C57BL/6 mice (n = 12/group) aged 4 to 6 weeks and weighing >15 g received a high-fat diet throughout this 45-day study. After a 7-day handling period, baseline levels of plasma glucose, plasma insulin and glycated haemoglobin (HbA1c) were assessed. Animals were allocated to one of six groups: compound vehicle control, intraperitoneal streptozotocin (STZ, 50 mg/kg)-treated control and saxagliptin (10 mg/kg) or sitagliptin (10 mg/kg, positive control) initiated 7 days before or 1 day after STZ administration. Endpoints included changes in body weight, food and water consumption, glucose tolerance (approximately 3 weeks post-STZ), fasting glucose and HbA1c and immunohistochemical analyses of the pancreas. Body weight, weight gain and food intake were reduced in STZ versus control mice. DPP-4 inhibitor treatment did not affect these changes, but the increase in water intake observed post-STZ administration was significantly attenuated with DPP-4 inhibitors whether initiated before or after STZ injury. Small but significant im...Continue Reading

References

Jun 17, 1998·Metabolism: Clinical and Experimental·J LuoG M Reaven
May 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stacey L ConarelloBei B Zhang
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Kathrin MaedlerMarc Y Donath
Jan 22, 2005·Science·Christopher J Rhodes
Dec 13, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Brian D GreenClifford J Bailey
Jan 16, 2007·Diabetes Research and Clinical Practice·F Xavier Pi-SunyerSylvie Dejager
Mar 22, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S DejagerA Schweizer
Apr 5, 2007·Current Medical Research and Opinion·Claresa Levetan
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Julio Rosenstock, Bernard Zinman
Dec 23, 2008·Diabetes Research and Clinical Practice·Viswanathan MohanKeith D Kaufman
Aug 5, 2009·Current Medical Research and Opinion·J RosenstockUNKNOWN CV181-011 Study Investigators
Oct 6, 2009·Journal of the American Pharmacists Association : JAPhA·R Keith Campbell
Nov 26, 2009·Expert Opinion on Pharmacotherapy·Jay H ShubrookFrank L Schwartz
Apr 24, 2010·Pharmacotherapy·Joshua J NeumillerR Keith Campbell
Jul 14, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K MiuraS Yamagishi
Sep 3, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Joshua J Neumiller, R Keith Campbell
Oct 30, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kavita NyalakondaFaramarz Ismail-Beigi

❮ Previous
Next ❯

Citations

Nov 28, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaidingerM D Säemann
Feb 18, 2015·Nature Reviews. Endocrinology·Paolo PozzilliRaffaella Buzzetti
Jul 6, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Princess Urbina, Dinender K Singla
Apr 15, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Yuwei ZhangWeiping Min
Apr 23, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Mikaela SjöstrandBoaz Hirshberg
Nov 7, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kai Guo, Faguang Jin
Feb 20, 2015·Metabolic Brain Disease·Tomás P BachorAngela M Suburo
Jul 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing GaoXueying Mao
Jun 2, 2018·Journal of Diabetes Research·Jacqueline H ParillaSakeneh Zraika
Aug 14, 2020·Journal of Ethnopharmacology·Raafat A Abdel-AalLaila A Ali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.