Effects of scalp electroacupuncture on the PI3K/Akt signalling pathway and apoptosis of hippocampal neurons in a rat model of cerebral palsy

Acupuncture in Medicine : Journal of the British Medical Acupuncture Society
Hanhong ZhangKaiyun Chen

Abstract

Background Substantial evidence from clinical reports has established that most cerebral palsy (CP) patients benefit from a comprehensive rehabilitation exercise training programme. Such advances are enhanced when scalp electroacupuncture (EA), applied at a location corresponding to the projection of the motor area, is combined with rehabilitation exercise training. However, little information exists regarding the mechanistic basis for these effects. Objective To examine whether EA stimulation within the scalp projection location of the motor area can inhibit apoptosis of hippocampal neurons by regulating the PI3k/Akt signalling pathway in a rat model of CP. Methods Fifty male Sprague-Dawley rats underwent surgical modelling of CP. Five were used to confirm successful establishment of the model and the remaining 45 rats were randomly divided into one of three groups that remained untreated (CP group, n=15) or received EA treatment alone (CP+EA group, n=15) or EA in combination with a PI3K/Akt inhibitor (CP+EA+LY294002 group, n=15)). An otherwise healthy negative control group of rats undergoing sham surgery was also included (Control group, n=15). In the CP+EA and CP+EA+LY294002 groups, EA was applied to the scalp surface at al...Continue Reading

References

Nov 13, 2002·Journal of Neurotrauma·Stephen W ScheffMary E Cain
Feb 17, 2007·The Biochemical Journal·Severine I GharbiMichael D Waterfield
Sep 28, 2010·The Orthopedic Clinics of North America·Eve Blair
Apr 24, 2012·Annals of Neurology·Laura BennetAlistair Jan Gunn
Dec 22, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·K Klebermass-SchrehofN Haiden
Mar 1, 2012·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Jason Jishun HaoYang Tiansong
Aug 11, 2015·American Journal of Physical Medicine & Rehabilitation·Tiffany Rivenburgh
Nov 13, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xianwei ZhuLu Bai
Dec 15, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xinsheng LaiBingbing Nie
Jan 19, 2016·Frontiers in Neuroanatomy·Roustem KhazipovAlfonso Represa
Mar 31, 2016·Developmental Medicine and Child Neurology·Catherine MorganLinda Fetters
Jul 13, 2016·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Min ZhangYan Ji

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