PMID: 9443759Jan 27, 1998Paper

Effects of scatter and attenuation correction on quantitative assessment of regional cerebral blood flow with SPECT

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
H IidaS Eberl

Abstract

Appropriate corrections for scatter and attenuation correction are prerequisites for quantitative SPECT studies. However, in most cerebral SPECT studies, uniform attenuation in the head is assumed, and scatter is usually neglected. This study evaluated the effect of attenuation correction and scatter correction on quantitative values and image contrast. Studies were performed in six normal volunteers (ages 22-26 yr) following intravenous 123I-IMP administration using a rotating, dual-head gamma camera. A transmission scan was acquired with a 99mTc rod source (74 MBq) placed at the focus of a symmetrical fanbeam collimator. Data were reconstructed using two attenuation coefficient (mu) maps: quantitative mu map from the transmission scan and a uniform mu map generated by edge detection of the reconstructed images. Narrow and broad beam mu values were used with and without scatter correction, respectively. Scatter was corrected with transmission-dependent convolution subtraction and triple-energy window techniques. Quantitative rCBF images were calculated by the previously validated IMP-autoradiographic technique, and they were compared with those obtained by (15)O-water and PET. SPECT and PET images were registered to MRI studie...Continue Reading

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