Mar 18, 2000

Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats

European Journal of Pharmacology
Carrie K Jones, Harlan E Shannon


The potential involvement of the muscarinic cholinergic system in the underlying mechanisms of prepulse inhibition of the acoustic startle reflex was evaluated in male Sprague-Dawley rats under conditions of varying dose, prepulse intensity, and interstimulus interval. The effects of scopolamine on prepulse inhibition were also directly compared with the effects observed using apomorphine and phencyclidine under the same test parameters. Scopolamine (0. 03-1.0 mg/kg) produced a significant dose-dependent decrease in prepulse inhibition, but had no effect on startle amplitude over the dose range tested. Apomorphine (0.03-1.0 mg/kg) and phencyclidine (0. 1-5.6 mg/kg) produced significant dose-dependent decreases in prepulse inhibition and changes in startle amplitude. The scopolamine-induced decrease in prepulse inhibition varied with prepulse intensity in that the changes produced by scopolamine became smaller in magnitude as the prepulse intensity was increased from 9 to 30 dB above background. On the other hand, apomorphine and phencyclidine decreased prepulse inhibition to approximately the same magnitude across all prepulse intensities tested. The observed decreases in prepulse inhibition produced by scopolamine, apomorphine...Continue Reading

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Mentioned in this Paper

Phencyclidine Hydrobromide
Isopto Hyoscine
Startle Reaction
Prepulse Inhibition Activity
Acoustic Stimulation
Excitatory Amino Acid Antagonists
Rats, Sprague-Dawley

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