Feb 6, 2010

Effects of scrotal insulation and pathological lesions on alpha-Smooth Muscle Actin (SMA) and vimentin in the bull testes

The Journal of Reproduction and Development
Bhuminand DevkotaYoh-Ichi Miyake

Abstract

The expression patterns of alpha-smooth muscle actin (SMA) and vimentin in the bovine testis indicate the maturation status of seminiferous tubules. The present study demonstrates the effects of impaired spermatogenesis resulting from increased testicular temperature after scrotal insulation and pathological lesions in subfertile bull testes on the changes in immunohistochemical expression of alpha-SMA and vimentin. Scrotal insulation induced degenerative changes of seminiferous tubules, and subfertile bull testes demonstrated characteristic mixed atrophied lesions; dysplastic lesions were seen in one bull. The increased intensity of peritubular alpha-SMA in the dysplastic area was distinct and indicated shrinkage of the seminiferous tubules. The mixed atrophied lesions revealed unaltered expression of peritubular alpha-SMA. However, considerable distortion was observed in the expression of alpha-SMA in severely degenerated tubules after insulation, which may indicate the heat sensitivity of peritubular alpha-SMA or its relation with spermatogenic activity under sudden heat stress. The vimentin expression pattern in the degenerated tubules of post-insulated testes was unaltered. However, the Sertoli cell-only tubules of mixed a...Continue Reading

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Citations

Mentioned in this Paper

Benign Neoplasm of Testis
VIM gene
Abnormal Degeneration
Scrotum
Isoactin
Neoplasm of Uncertain or Unknown Behavior of Testis
Bos taurus
Biologic Development
Immunocytochemistry
Orchiectomy

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