PMID: 8599187Oct 1, 1995Paper

Effects of sea anemone (Heteractis magnifica and Actinia equina) cytolysins on synaptosomal uptake of GABA and choline

Toxicon : Official Journal of the International Society on Toxinology
H E KhooC H Tan

Abstract

Magnificalysin I and II (HMg I and II) and equinatoxin II (EqTx II) are cytolytic toxins extracted from sea anemones Heteractis magnifica and Actinia equina, respectively. They induced haemolysis in rat red blood cells and inhibited gamma amino butyric acid (GABA) and choline uptake into rat brain synaptosomes. These effects were concentration dependent. The inhibition of GABA and choline uptake could be overcome by the addition of exogenous sphingomyelin, suggesting that there might be interaction between these cytolysins and the phospholipid. Although the precise mechanisms involved in haemolysis and inhibition of GABA and choline uptake are unknown, they appeared to be different.

References

Oct 1, 1979·Neuroscience Letters·C H Tan, S J Abkowitz
Jan 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·R S NortonR J Simpson
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·C L HoI Ferlan
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·P Macek, D Lebez
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Dec 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·K S KhooM C Chung
Jan 1, 1988·Neurochemistry International·C H TanF H Ng

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Citations

Nov 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·Gregor Anderluh, Peter Macek
May 31, 2011·Biochimica Et Biophysica Acta·Lucía García-OrtegaJosé G Gavilanes
Mar 17, 1997·Biochemical and Biophysical Research Communications·H E KhooD Chen
Apr 22, 2008·Toxicon : Official Journal of the International Society on Toxinology·Yawen WangHoon Eng Khoo

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