Effects of sebum on drug transport across the human stratum corneum in vivo

Skin Pharmacology and Physiology
J-C TsaiH-M Sheu

Abstract

The objective of this study was to investigate the effect of sebum on drug transport across the human stratum corneum (SC) in vivo for two model compounds, 4-cyanophenol (CP) and cimetidine (CM), of different lipophilicity and molecular size by utilizing noninvasive tape-stripping techniques, in conjunction with an unsteady-state diffusion model for data analysis. The results demonstrated that the SC permeability of the relatively hydrophilic CM on the forehead may be as much as four times the permeability on the forearm. The administration of sebum supplementation to the forearm increased the SC permeability of CM more than threefold, but did not have the same effect with regard to CP. Removal of sebum from the forehead demonstrated a small but significant effect (-22%) on the SC permeability of CM. The presence of sebum on the forehead or forearm increased the diffusion of both molecules, but the effect on partition varied between sites and drugs. The change in the SC permeability of the relatively hydrophilic drug using sebum treatment may be attributable to the altered barrier function of the SC due to the disordering structures of the intercellular lipid molecules.

References

Nov 1, 1990·Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology·T Tsuji
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R O Potts, M L Francoeur
Jan 1, 1987·Journal of Pharmaceutical Sciences·G M GoldenR O Potts
Dec 1, 1986·The Journal of Investigative Dermatology·G ImokawaN Yoshizuka
Apr 1, 1985·The Journal of Investigative Dermatology·G Imokawa, M Hattori
Mar 1, 1970·The Journal of Investigative Dermatology·R S GreeneJ S Strauss
Aug 1, 1984·The Journal of Investigative Dermatology·S C GreenD T Downing
Oct 1, 1982·The Journal of Investigative Dermatology·D T DowningJ S Strauss
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·F PirotR H Guy
May 7, 1998·Chemistry and Physics of Lipids·P W Wertz, B van den Bergh
Aug 1, 1963·The British Journal of Dermatology·A M KLIGMAN
Jul 13, 2007·International Journal of Pharmaceutics·Satyanarayana Valiveti, Guang Wei Lu
Jul 27, 2007·International Journal of Pharmaceutics·Satyanarayana ValivetiGuang Wei Lu

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Citations

Feb 1, 1996·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·G E Piérard
Feb 26, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Désirée SchneiderGintautas Korinth
Feb 15, 2015·Journal of Dermatological Science·Jiun-Wen GuoHamm-Ming Sheu
Jan 5, 2019·Physical Chemistry Chemical Physics : PCCP·Anna Sofia TasciniFernando Bresme
Jan 3, 2018·Physical Chemistry Chemical Physics : PCCP·Anna Sofia TasciniFernando Bresme
Jul 10, 2020·Cutaneous and Ocular Toxicology·Jordan L Bormann, Howard I Maibach
Jun 17, 2019·Skin Pharmacology and Physiology·Allison K RushGerald B Kasting

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