Effects of secondary flow caused by a curved channel on plasma protein adsorption to artificial surfaces

Biotechnology Progress
N PfeifferE F Leonard

Abstract

The effects of secondary flow induced by a curved channel on fibrinogen deposition and replacement on a glass surface were studied. Platelet adhesion to surface-bound fibrinogen was also studied to indicate how secondary flow may affect thrombogenesis on artificial surfaces. A saline pre-wetted channel with straight and curved sections was exposed to flowing plasma at a Reynolds number of 28.6. Results show that fibrinogen deposited on the surface at a shear rate of 175 s-1 was replaced faster in regions of secondary flow (Dean numbers from 11 to 19) than in adjacent regions of shear flow. Platelets adhered only to those surfaces where fibrinogen had been detected.

Citations

Oct 3, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Warwick S NesbittShaun P Jackson
Oct 7, 2008·Journal of Neurosurgery·Christoph TschanJoachim Oertel
May 7, 2002·Journal of Neurosurgery·Juergen PiekMichael Robert Gaab
Mar 24, 2004·Journal of Neurosurgery·Joachim OertelJürgen Piek

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