Effects of secretin and gastric inhibitory polypeptide on human pancreatic growth hormone-releasing factor(1-40)-stimulated growth hormone levels in the rat

Biochemical and Biophysical Research Communications
W A MurphyD H Coy

Abstract

Synthetic human pancreatic growth hormone-releasing factor containing 40 amino acids ([hpGRF (1-40)]-OH) significantly stimulated plasma growth hormone (GH) levels in both sodium pentobarbital and urethane anesthetized rats. Synthetic secretin, gastric inhibitory polypeptide (GIP), and glucagon significantly decreased plasma GH levels while synthetic vasoactive intestinal peptide (VIP) had no effect. Secretin and GIP also altered the in vivo plasma GH response to [hpGRF(1-40)]-OH. Whether this effect is the result of an interaction at the pituitary level or is due to an extra-pituitary effect of secretin and GIP awaits further study.

Citations

Jan 1, 1986·Peptides·W KönigJ Sandow
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·T R HallC G Scanes
Aug 1, 1986·Clinics in Endocrinology and Metabolism·B B Bercu, F B Diamond
Feb 29, 1984·Biochemical and Biophysical Research Communications·V A LanceD H Coy

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