PMID: 8971731Dec 1, 1996Paper

Effects of secretogranin II-derived peptides on the release of neurotransmitters monitored in the basal ganglia of the rat with in vivo microdialysis

Naunyn-Schmiedeberg's Archives of Pharmacology
Z B YouM Herrera-Marschitz

Abstract

In vivo microdialysis was used to study the effect of secretogranin II-derived peptides on dynorphin B (Dyn B), dopamine, gamma-aminobutyric acid (GABA), glutamate and aspartate release in the substantia nigra and neostriatum of halothane-anaesthesized rats. In the substantia nigra, local infusion of secretoneurin (secretogranin II 154-186) (1-50 microM) increased, in a concentration-dependent manner, extracellular aspartate, glutamate, Dyn B, dopamine and GABA levels. The effect was particularly prominent on aspartate and glutamate levels which, following 50 microM of secretoneurin, were increased by > 20 and > 10 fold, respectively. However, the effect of secretoneurin on Dyn B release appeared to be more specific, since a significant increase (> 20 fold) was already observed following 1 microM of secretoneurin. In the neostriatum, Dyn B, glutamate, aspartate and GABA levels were also increased by local secretoneurin infusion, but the effect was less prominent than in the substantia nigra. In the substantia nigra, only Dyn B levels were significantly increased following infusion of 10 microM of the secretoneurin-C terminal (secretoneurin-15C), whereas Dyn B and GABA levels were increased by the same concentration of the secre...Continue Reading

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Citations

Nov 11, 2003·Trends in Pharmacological Sciences·Edwin H JacobsAnton N M Schoffelmeer
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·A Kuzmin, B Johansson
Jan 12, 2002·Regulatory Peptides·Gudrun WakoniggAlois Saria
Apr 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·E ZhaoVance L Trudeau
Aug 25, 2011·Endocrine Reviews·Alessandro BartolomucciStephen R J Salton
Jul 9, 1998·Journal of Neuroimmunology·C SchneitlerR Fischer-Colbrie
Oct 12, 2010·Neurochemical Research·Rafal M KaminskiJeffrey M Witkin
Jun 16, 2009·General and Comparative Endocrinology·E ZhaoVance L Trudeau
Feb 3, 2005·Biological Reviews of the Cambridge Philosophical Society·Karen B Helle
Oct 12, 2013·Journal of Neurochemistry·Katsuro IwaseMasaki Takiguchi
Mar 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marian L LogripDorit Ron
Sep 1, 2017·Cellular and Molecular Life Sciences : CMLS·Wei LiHong Tian

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