PMID: 8593754Jul 1, 1995Paper

Effects of seishin-renshi-in and Gymnema sylvestre on insulin resistance in streptozotocin-induced diabetic rats

Diabetes Research and Clinical Practice
M TominagaH Manaka

Abstract

Although there is no concept of insulin resistance in traditional Kampo (Chinese) medicine and Indian medicine, we had the hypothesis that some drug in a mixture of crude drugs which was believed to ameliorate diabetes mellitus may have had the effect of improving insulin resistance. To test this hypothesis, the effects of Seishin-renshi-in (Chinese medicine) and Gymnema sylvestre (Indian medicine) on the insulin resistance of streptozotocin-induced diabetic rats was studied by the glucose clamp technique. Oral administration of Seishin-renshi-in (800 mg/kg/day) with injections of a minimum dose of Ultralente insulin decreased urine volume and urinary glucose excretion during a 7-day treatment period and improved the insulin stimulated glucose uptake in peripheral tissues, as well as improving the insulin suppressed hepatic glucose output during glucose clamp. However, G. sylvestre (120 mg/kg/day) treatment did not improve insulin resistance. We conclude that Seishin-renshi-in, with a small dose of insulin, improved insulin resistance in streptozotocin-induced diabetic rats, but Gymnema sylvestre did not.

Citations

May 22, 2002·Journal of Ethnopharmacology·J K GroverV Vats
Jun 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·L WangK Shimamoto
Aug 20, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ling WangKazuaki Shimamoto
May 9, 2006·Journal of Ethnopharmacology·Pulok K MukherjeePeter J Houghton
Dec 22, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M StracquadanioM A Palumbo
Oct 6, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Omar FaridMohamed Eddouks
Oct 12, 2004·American Journal of Physiology. Cell Physiology·Pavel ZhabyeyevTerence F McDonald
Feb 19, 2014·Journal of the American College of Nutrition·Pnina Rotman-PikielnyYair Levy
Aug 31, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Rashmi S ShenoyH K Manonmani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.