Effects of selected pharmaceutical products on phagocytic activity in Elliptio complanata mussels

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
F GagnéP D Hansen

Abstract

Municipal wastewaters are recognized as a major source of pharmaceutical and personal care products to the aquatic environment, thereby exposing biota to unknown chronic effects. This study sought to examine the immunotoxic effects of pharmaceutical and urban waste products on the freshwater mussel Elliptio complanata. Hemolymph samples were collected and treated in vitro with increasing concentrations of various drugs (bezafibrate, carbamazepine, fluoxetine, gemfibrozil, morphine, naproxen, novobiocin, oxytetracycline, sulfamethazole, sulfapyridine and trimethoprim) and urban waste related chemicals (coprostanol, caffeine, cotinine) for 24 h at 15 degrees C. In a parallel experiment, mussels were caged and placed in two final aeration lagoons for the treatment of domestic wastewaters. At the end of the exposure period, hemolymphs were tested for phagocytic activity, intracellular esterase activity, cell adherence and lipid peroxidation (LPO). The products that most increased phagocytosis were bezafibrate, gemfibrozil and trimethoprim, while novobiocin and morphine reduced its activity. Intracellular esterase activity was reduced most strongly with sulfamethazole, novobiocin, gemfibrozil, bezafibrate and carbamazepine. Cell adh...Continue Reading

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Citations

Oct 20, 2009·Analytical and Bioanalytical Chemistry·Montserrat SoléThomas H Hutchinson
Oct 11, 2015·Environmental Science and Pollution Research International·Ali SharifAmmara Saleem
Sep 14, 2010·Water Research·Chong-Jian TangDa-Tian Wu
Apr 20, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·F GagnéM Gélinas
May 12, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Marco ParoliniAlfredo Provini
Feb 24, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·A BinelliA Provini
Mar 10, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Laura CanesiAntonio Marcomini
May 7, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ângela AlmeidaEtelvina Figueira
Jun 26, 2012·The Science of the Total Environment·Raktim PalRavi Naidu
Aug 8, 2014·Environmental Science and Pollution Research International·Avik J GhoshdastidarAnthony Z Tong
Jan 1, 2014·Paediatric Anaesthesia·Priti G DalalCheston Berlin

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