Effects of selective and non-selective beta-adrenergic agents on insulin secretion in vivo

European Journal of Pharmacology
B Ahrén, I Lundquist

Abstract

The effects of various beta-adrenergic agents on insulin secretion were investigated in vivo in mice. The non-selective beta-stimulator isopropylnoradrenaline and the selective beta 2-stimulator terbutaline both stimulated insulin secretion markedly, with the same efficacy and in a dose-dependent manner. The peak levels of plasma insulin after these two beta-agonists were achieved at a later time point (5-6 min) than after stimulation with glucose or carbachol (1.5-2.5 min). At very high dose levels the beta 2-stimulator isopropylaminothiazoloxypropanol slightly increased plasma insulin concentrations. The non-selective beta-blocker propranolol and the beta 2-selective blocker ICI 188,551 inhibited terbutaline-induced insulin release markedly and at comparable low dose levels, whereas the selective beta 1-blocker metoprolol exerted this effect only at a high dose level. At higher dose levels these three blockers moderately depressed the insulin response to glucose suggesting a partial dependence on intact beta-adrenoceptors for the effect of glucose. The beta 2-blocker butoxamine and the beta 1-blocker pamatolol did not influence insulin secretion. In conclusion, beta-adrenoceptor stimulation enhanced insulin secretion in vivo,...Continue Reading

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Citations

May 4, 1984·European Journal of Pharmacology·C WilsonJ R Arch
Jun 15, 1984·European Journal of Pharmacology·B Ahrén, I Lundquist
Jun 23, 1995·European Journal of Pharmacology·B AhrénA B Steffens
Apr 21, 1998·European Journal of Pharmacology·S Karlsson, B Ahrén
Jul 1, 1989·The Proceedings of the Nutrition Society·J R Arch
Jun 8, 2011·Metabolic Syndrome and Related Disorders·Naohiko Ueno, Yoshiko Satou
Apr 1, 1991·British Journal of Pharmacology·B Ahrén
Mar 1, 1987·Acta Physiologica Scandinavica·S Lindskog, B Ahrén
Mar 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Saori MukaidaTore Bengtsson
Sep 10, 2003·Endocrinology·Linda Ste Marie, Richard D Palmiter
Jun 5, 1998·The American Journal of Physiology·K FilipssonB Ahrén
Jan 1, 1986·Acta Medica Scandinavica·B Ahrén
Nov 1, 1993·Medicinal Research Reviews·J R Arch, A J Kaumann
Nov 7, 2001·BMC Endocrine Disorders·Maria I Borelli, Juan J Gagliardino
Nov 1, 1988·The American Journal of Physiology·B Ahrén
Jul 1, 1993·The American Journal of Physiology·A Salehi, I Lundquist
Dec 16, 2020·Diabetes, Obesity & Metabolism·Dsh Bell, E Goncalves

Related Concepts

H110/38
ICI 118551, hydrochloride
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
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Dose-Response Relationship, Drug
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Insulin B Chain

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