Effects of selective cholinergic antagonists and alpha,beta-methylene ATP on guinea-pig urinary bladder contractions in vivo following pelvic nerve stimulation

Journal of Autonomic Pharmacology
J S Peterson, L Noronha-Blob

Abstract

1. An in vivo preparation measuring functional detrusor muscle strength in terms of intravesical bladder pressure (Pves) following in situ pelvic nerve stimulation has been developed in urethane-anaesthetized guinea pigs. 2. The increase in bladder pressure following pelvic nerve stimulation was abolished by topical lidocaine or tetrodotoxin, suggesting a neurogenic origin for the in vivo contractile response. 3. Cholinergic antagonists (i.v.) decreased the amplitude of the peak pressure response by about 50% at both high (30 Hz) and low (5 Hz) stimulation rates, with a rank order of potency of atropine greater than propantheline greater than oxybutynin greater than hexahydrosiladifenidol greater than pirenzepine greater than methoctramine. 4. The P2 purine receptor antagonist, alpha,beta-methylene ATP (i.v.), antagonized pelvic nerve-stimulated bladder contractions differentially at 5 and 30 Hz. At low frequencies, alpha, beta-methylene ATP was both more potent (2.5-fold) and more efficacious (-77 compared to -55% delta) than at 30 Hz. Atropine and alpha,beta-methylene ATP together completely inhibited the contractile response. 5. Together, the findings indicate that in guinea pigs, urinary bladder contractions induced by pelv...Continue Reading

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Citations

Jan 1, 1996·Neurourology and Urodynamics·T Watanabe, C E Constantinou
Dec 15, 2000·Progress in Pediatric Cardiology·S LatifiJ L Blumer
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Jan 25, 2007·Basic & Clinical Pharmacology & Toxicology·Daniel GiglioGunnar Tobin
Aug 21, 2019·British Journal of Pharmacology·Carly J McCarthyChristopher H Fry
Dec 12, 2002·Scandinavian Journal of Urology and Nephrology. Supplementum·A L DalmoseJ C Djurhuus
May 3, 2019·American Journal of Physiology. Cell Physiology·Zhihui FongGerard P Sergeant
Aug 3, 2021·Autonomic Neuroscience : Basic & Clinical·Charles Kennedy

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