PMID: 9165348May 1, 1997Paper

Effects of selective inner hair cell loss on auditory nerve fiber threshold, tuning and spontaneous and driven discharge rate

Hearing Research
J WangR J Salvi

Abstract

Current theories assume that the outer hair cells (OHC) are responsible for the sharp tuning and exquisite sensitivity of the ear whereas inner hair cells (IHC) are mainly responsible for transmitting acoustic information to the central nervous system. To further evaluate this model, we used a single (38 mg/kg) or double dose (38 mg/kg, 2 times) of carboplatin to produce a moderate (20-28%) or severe (60-95%) IHC loss while sparing a large proportion of the OHCs. The surviving OHCs were functionally intact as indicated by normal cochlear microphonic (CM) potentials and distortion product otoacoustic emissions (DPOAE). Single-unit responses were recorded from auditory nerve fibers to determine the effects of the moderate or severe IHC loss on the output of the surviving IHCs. Most neurons that responded to sound in the single-dose group had normal or near-normal thresholds and normal tuning. Relatively few neurons in the double-dose group responded to sound because of the severe IHC loss. The neurons that did respond to sound had narrow tuning curves. Some neurons in the double-dose group also had thresholds that were within the normal range, but most had thresholds that were elevated a mild-to-moderate degree. These results ind...Continue Reading

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Citations

Aug 30, 2000·Hearing Research·R J SalviD Ding
Dec 18, 2001·Hearing Research·L ChenR J Salvi
May 29, 2002·Hearing Research·Yingzhe LiRichard Salvi
Jul 12, 2003·Hearing Research·Jian WangRichard J Salvi
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Jan 18, 2007·The Journal of the Acoustical Society of America·Colleen G Le PrellDavid F Dolan
Jul 24, 2010·The Journal of the Acoustical Society of America·C D Cowper-SmithD P Phillips
May 12, 2009·The Journal of the Acoustical Society of America·Olaf Strelcyk, Torsten Dau
Jul 22, 1998·The Journal of the Acoustical Society of America·J D DurrantR J Salvi
Oct 24, 2012·Hearing Research·Arnaud J Noreña, Brandon J Farley
Aug 6, 2010·Hearing Research·Marcus MüllerJean W T Smolders
Dec 23, 2015·Journal of the Association for Research in Otolaryngology : JARO·Edward LobarinasDalian Ding
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Dalian DingRichard Salvi
Apr 30, 2015·Cell and Tissue Research·Peter Heil, Adam J Peterson
Dec 3, 2005·Behavioral and Brain Functions : BBF·Ajith U Kumar, M Jayaram
Dec 1, 2012·Journal of Otology·Ding DalianMasaru Tanokura
Jun 7, 2014·Frontiers in Neuroscience·Joshua R Gold, Victoria M Bajo
Nov 12, 2014·Frontiers in Neurology·Benjamin D AuerbachRichard J Salvi
Aug 21, 2002·The Journal of the Acoustical Society of America·Sally Arnold, Robert Burkard

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