PMID: 2497483Jan 1, 1989Paper

Effects of selective monoaminergic reuptake blockade on activity rhythms in developing rats

Psychopharmacology
N I BarberR J Baldessarini

Abstract

Developing rats display prominent ultradian rhythms of locomotor activity when separated from the litter. A pharmacological analysis was undertaken to provide preliminary data on the role of monoaminergic neurotransmitter systems in the modulation or manifestation of this fundamental biological rhythm. Twenty-four hour activity profiles were monitored in 15-day-old rats, tested in darkness, after intraperitoneal treatment with desipramine (DMI), zimelidine (ZMI), or GBR-13069 (GBR), selective uptake inhibitors of norepinephrine, serotonin, and dopamine, respectively. Time series data were analyzed by low-resolution variance spectral analysis. DMI significantly diminished ultradian (greater than 1 cycle per day; cpd) rhythmicity, and enhanced the circadian rhythm. Equimolar doses of ZMI had little effect on the ultradian band (7-15 cpd), but slightly reduced the circadian peak. The effects of acute GBR administration were complex, as this agent produced prominent effects on basal activity. In a second study these agents were administered continuously over a 5-day period, using subcutaneously implanted Alzet osmotic minipumps, to avoid the confounding effects of acute administration. Continuously-infused DMI virtually eliminated ...Continue Reading

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Citations

Jan 1, 1990·Progress in Neurobiology·A S Horn
Jul 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·M H TeicherK Pahlavan
Feb 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·C A GlodY Ito
Apr 18, 2013·Synapse·Ronald M Salomon, Ronald L Cowan

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