Effects of selenium deficiency on diaphragmatic function after resistive loading

Acta Physiologica Scandinavica
F H AndradeL C Maxwell

Abstract

Diaphragmatic fatigue has been associated with increased production of reactive oxygen species. Among the defenses against reactive oxygen species is the glutathione redox system. The selenium-dependent enzyme glutathione peroxidase is an important component of this system. Thus, we hypothesized that selenium deficiency would lower glutathione peroxidase activity and render the diaphragm more susceptible to a mild exertional protocol. Sprague-Dawley rats were fed a selenium-deficient or control diet for 12 weeks then divided into four experimental groups: (1) unloaded, basic diet with selenium supplementation (control); (2) unloaded, selenium-deficient diet; (3) loaded, basic diet with selenium supplementation; and (4) loaded, selenium-deficient diet. Diaphragmatic in vitro contractile properties, glutathione peroxidase activity and glutathione content were measured. During inspiratory resistive loading, the animals breathed against an inspiratory resistor at 70% of maximal airway pressure until the target pressure was not achieved for five consecutive breaths. Selenium deficiency resulted in a significant decrease in diaphragmatic glutathione peroxidase activity, without changes in total glutathione content. Neither selenium d...Continue Reading

Citations

Dec 6, 2005·Pflügers Archiv : European journal of physiology·Francisco H Andrade, Colleen A McMullen
Aug 19, 2005·BMC Physiology·Colleen A McMullenFrancisco H Andrade
Oct 19, 2011·The Journal of Surgical Research·Efstathios KotidisSpiros Papavramidis
Mar 29, 2008·Heart & Lung : the Journal of Critical Care·Janet D PierceRichard L Clancy
Nov 9, 2016·Nutrition & Metabolism·Dóra BodnárPéter Szentesi
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A Van Gossum, J Neve

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