PMID: 2110422May 1, 1990Paper

Effects of serosal hypertonicity on water permeability in toad urinary bladder

The American Journal of Physiology
W A KachadorianV A DiScala

Abstract

We studied in toad urinary bladder the effects of serosal hypertonicity on tissue water permeability, granular cell luminal membrane water permeability, and granular cell luminal membrane particle aggregates and compared them with effects of antidiuretic hormone (ADH). In tissues challenged by a hypertonic (447 mosmol/kgH2O) serosal bath, luminal membrane aggregates were structurally similar to those caused by ADH. The tissue water permeability increase induced by serosal hypertonicity was much less than that caused by a maximally stimulating concentration of ADH on tissue in isotonic serosal baths with approximately the same transmural gradient. The difference is explained not only by a reduced incidence of luminal membrane aggregates but also by an increased resistance to water movement at a postluminal membrane site. Measurements of luminal membrane water permeability showed a close correlation with luminal membrane aggregate frequency, indicating that the calculated permeability of an individual aggregate was a constant. Thus the relation of luminal membrane aggregates to tissue osmotic permeability is modified by serosal hypertonicity. Morphological examination of these tissues suggested that luminal membrane aggregates ma...Continue Reading

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Citations

Apr 11, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuki ShibataMasakazu Suzuki
Feb 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ann T Hanna-Mitchell, Elizabeth M Gebruers
Feb 3, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Masakazu SuzukiShigeyasu Tanaka

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