PMID: 9630002Jun 18, 1998Paper

Effects of serotonin 5-HT(2A/2C) antagonists on associative learning in the rabbit

Psychopharmacology
S E WelshJohn A Harvey

Abstract

The 5-HT(2A/2C) receptor antagonist, ritanserin, was reported to retard the acquisition of conditioned responses (CRs) during classical conditioning of the rabbit's nictitating membrane (NM) response. The present study compared the effects of ritanserin on acquisition of CRs to a tone conditioned stimulus (CS) with that of the 5-HT(2A/2C) receptor antagonist, LY-53,857 and the 5-HT2A selective antagonist, MDL-11,939. All three drugs were injected at equimolar doses of 0.067, 0.67 and 6.7 micromol/kg, SC, 1 h before behavioral testing. Ritanserin and MDL-11,939 retarded CR acquisition to a tone CS, while LY-53,857 had no effect. Control experiments demonstrated that ritanserin (1 micromol/kg), MDL-11,939 (1 micromol/kg) and LY-53,857 (2 micromol/kg) had no effect on baseline responding or non-associative responding to the CS. However, both ritanserin and MDL-11,939 impaired the performance of the unconditioned NM reflex, as measured by a decrease in UR amplitudes on US alone trials, while LY-53,857 had no effect. In previously trained animals, ritanserin robustly impaired the performance of CRs, as measured by a reduced ability of the CS to elicit CRs, while the effects of LY-53,857 and MDL-11,939 were marginal. The retardation ...Continue Reading

Citations

Jan 23, 1999·Biological Psychiatry·J I FriedmanK L Davis
Aug 12, 2003·European Journal of Pharmacology·Gerard J Marek
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·A G RomanoJ A Harvey
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Meneses
Jan 22, 2013·ACS Chemical Neuroscience·James B Hanks, Javier González-Maeso
Oct 15, 2003·Learning & Memory·John A Harvey
Jul 26, 2012·Clinical & Developmental Immunology·Anna Jane BattersbySarah Burl
Jul 5, 2005·Expert Opinion on Investigational Drugs·F JenckJ L Moreau
Dec 27, 2008·Pharmacology & Therapeutics·V J AloyoJ A Harvey
Oct 27, 2015·Frontiers in Pharmacology·Gongliang Zhang, Robert W Stackman
Nov 4, 2006·European Journal of Pharmacology·Peter J Greasley, John C Clapham
Jul 18, 2006·Neuropharmacology·T M MosherA J Greenshaw
Jan 29, 2014·Attention, Perception & Psychophysics·Nuno De Sá Teixeira, Heiko Hecht
Oct 31, 2018·The Journal of Pharmacology and Experimental Therapeutics·Dennis J ShollerKathryn A Cunningham
Jun 22, 2019·Pharmacological Reviews·R L Carhart-Harris, K J Friston
Sep 1, 2017·Journal of Psychopharmacology·R L Carhart-Harris, D J Nutt
Nov 12, 2020·Journal of Psychopharmacology·Ari Brouwer, Robin Lester Carhart-Harris
Jan 21, 2020·Neuropharmacology·Philippe De DeurwaerdèreGiuseppe Di Giovanni
Mar 25, 2021·Journal of Neurophysiology·Kevin J Cummings

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