PMID: 6168391Aug 1, 1981Paper

Effects of serotonin and catecholamines on RNA synthesis in planarians; in vitro and in vivo studies

Cell Differentiation
R Franquinet, I Martelly

Abstract

The effects of serotonin, dopamine and noradrenaline on RNA synthesis, estimated by the incorporation of [3H]orotic acid, were studied on regenerating fragments of planarians. Serotonin was observed to inhibit, whereas dopamine and noradrenaline had no apparent action. These three neurohormones and their antagonists were also tested on planarian cell cultures, using [3H]-uridine as tracer. RNA synthesis, inhibited by serotonin, methiothepine (serotonin antagonist) and fluphenazine (dopamine antagonist), was shown to be restored by dopamine. The effects of serotonin, dopamine and their antagonists, are discussed in relation to the adenylate cyclase system.

References

Nov 1, 1979·Molecular and Cellular Biochemistry·J F WhitfieldB K Tsang
Jan 1, 1976·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R FranquinetJ Hanqune
Jan 1, 1980·Reproduction, Nutrition, Development·I Martelly, A Le Moigne
May 8, 1980·Nature·A R Means, J R Dedman
Jul 31, 1980·Biochemical and Biophysical Research Communications·A L BoyntonJ P MacManus

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Citations

Jan 1, 1983·Psychoneuroendocrinology·J M Lauder
Feb 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R R ShelkeT R Raju
Jan 5, 2011·BMC Genomics·Josep F AbrilEmili Saló
Feb 26, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Francesca R ButtarelliFrancesco E Pontieri

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