PMID: 7019933Jun 1, 1981Paper

Effects of serotonin and L-5-hydroxytryptophan on plasma renin activity in rats

Pharmacology, Biochemistry, and Behavior
C C BarneyM J Fregly

Abstract

The effects of dipsogenic doses of l-5-hydroxytryptophan (5-HTP) and serotonin on plasma renin activity (PRA), blood pressure, and body temperature were determined in unanesthetized female rats. Both serotonin (2 mg/kg, s.c.) and 5-HTP (25 mg/kg, s.c.) induced six-fold increases in PRA measured 1 hr after drug administration. The central and peripheral decarboxylase inhibitor, benserazide (30 mg/kg, s.c.), as well as the peripheral decarboxylase inhibitor, carbidopa (6.5 mg/kg s.c.), prevented the increase in PRA associated with administration of 5-HTP. This suggests that 5-HTP must be converted to serotonin peripherally to increase PRA. At the doses used, serotonin decreased mean blood pressure and colonic temperature of unanesthetized rats while 5-HTP was without effect. The increase in PRA induced by 5-HTP does not appear, therefore, to be a response to either hypotension or a decrease in colonic temperature. Since 5-HTP must be converted to serotonin to initiate both a drinking response and an increase in PRA, the results suggest that the decrease in blood pressure and colonic temperature following administration of serotonin may not be important in induction of the drinking response and the increase in PRA. The mechanism b...Continue Reading

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Citations

Mar 26, 1982·European Journal of Pharmacology·S P Baker, M J Katovich
Jun 1, 1985·Physiology & Behavior·F S KralyM S Trattner
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·D C KiktaJ E Greenleaf
Sep 1, 1983·Pharmacology, Biochemistry, and Behavior·D C KiktaJ E Greenleaf
Apr 1, 1987·Brain Research Bulletin·N E RowlandM J Fregly
Mar 13, 2012·Pharmacological Reviews·Stephanie W WattsSusan M Barman
Oct 1, 1985·The Journal of Clinical Investigation·Y ShenkerR J Grekin
Jul 23, 1998·Physiological Reviews·J T Fitzsimons

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